ApoA-IV: current and emerging roles in intestinal lipid metabolism, glucose homeostasis, and satiety

Apolipoprotein A-IV (apoA-IV) is secreted by the small intestine on chylomicrons into intestinal lymph in response to fat absorption. Many physiological functions have been ascribed to apoA-IV, including a role in chylomicron assembly and lipid metabolism, a mediator of reverse-cholesterol transport...

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Bibliographic Details
Published in:American journal of physiology: Gastrointestinal and liver physiology 2015-03, Vol.308 (6), p.G472-G481
Main Authors: Kohan, Alison B, Wang, Fei, Lo, Chun-Min, Liu, Min, Tso, Patrick
Format: Article
Language:English
Subjects:
Animals
Apolipoproteins
Apolipoproteins A - metabolism
Brain - metabolism
Chylomicrons - metabolism
Diabetes
Digestive system
Eating
Energy Metabolism
Feeding Behavior
Glucose - metabolism
Homeostasis
Humans
Intestinal Absorption
Intestine, Small - metabolism
Lipid Metabolism
Lipids
Metabolism
Review
Satiety Response
Signal Transduction
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Summary:Apolipoprotein A-IV (apoA-IV) is secreted by the small intestine on chylomicrons into intestinal lymph in response to fat absorption. Many physiological functions have been ascribed to apoA-IV, including a role in chylomicron assembly and lipid metabolism, a mediator of reverse-cholesterol transport, an acute satiety factor, a regulator of gastric function, and, finally, a modulator of blood glucose homeostasis. The purpose of this review is to update our current view of intestinal apoA-IV synthesis and secretion and the physiological roles of apoA-IV in lipid metabolism and energy homeostasis, and to underscore the potential for intestinal apoA-IV to serve as a therapeutic target for the treatment of diabetes and obesity-related disease.
ISSN:0193-1857
1522-1547
DOI:10.1152/ajpgi.00098.2014