Lack of Association between JAK3 Gene Polymorphisms and Cardiovascular Disease in Spanish Patients with Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. JAK/STAT signalling pathway is involved in autoimmune diseases and in the atherosclerotic process. JAK3 is a highly promising target for immunomodulatory drugs an...

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Bibliographic Details
Published in:	BioMed research international 2015-01, Vol.2015, p.318364-11
Main Authors:	García-Bermúdez, Mercedes, López-Mejías, Raquel, Genre, Fernanda, Castañeda, Santos, Corrales, Alfonso, Llorca, Javier, González-Juanatey, Carlos, Ubilla, Begoña, Miranda-Filloy, José A., Pina, Trinitario, Gómez-Vaquero, Carmen, Rodríguez-Rodríguez, Luis, Fernández-Gutiérrez, Benjamín, Balsa, Alejandro, Pascual-Salcedo, Dora, López-Longo, Francisco J., Carreira, Patricia, Blanco, Ricardo, Martín, Javier, González-Gay, Miguel A.
Format:	Article
Language:	eng
Subjects:	Acute coronary syndromes Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - enzymology Arthritis, Rheumatoid - genetics Atherosclerosis C-Reactive Protein - metabolism Cardiovascular diseases Cardiovascular Diseases - complications Cardiovascular Diseases - enzymology Cardiovascular Diseases - genetics Carotid Intima-Media Thickness Colleges & universities Cytokines Demography Disease Drug therapy Epidemiology Female Gene Frequency - genetics Genes Genetic aspects Genetic Association Studies Genetic polymorphisms Genetic Predisposition to Disease Genomics Hospitals Humans Janus Kinase 3 - genetics Male Middle Aged Observations Peptides, Cyclic - metabolism Plaque, Atherosclerotic - complications Plaque, Atherosclerotic - enzymology Plaque, Atherosclerotic - genetics Polymorphism, Single Nucleotide - genetics Rheumatic diseases Rheumatoid arthritis Rheumatology Risk factors Signal transduction
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Summary:	Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. JAK/STAT signalling pathway is involved in autoimmune diseases and in the atherosclerotic process. JAK3 is a highly promising target for immunomodulatory drugs and polymorphisms in JAK3 gene have been associated with CV events in incident dialysis patients. Therefore, the aim of this study was to assess the potential role of JAK3 polymorphisms in the development of CV disease in patients with RA. 2136 Spanish RA patients were genotyped for the rs3212780 and rs3212752 JAK3 gene polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 539 of these patients by carotid ultrasonography (US). No statistically significant differences were found when each polymorphism was assessed according to carotid intima-media thickness values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV events after adjusting for potential confounders. In conclusion, our results do not confirm association between JAK3 polymorphisms and CV disease in RA.
ISSN:	2314-6133 2314-6141