Partial trisomy 2q33.3-q37.3 in a patient with an inverted duplicated neocentric marker chromosome

Increasing number of cases with small supernumerary marker chromosomes (sSMCs) without centromeric DNA and dozens of cases with trisomy 2q3 have been reported in recent years. However, cases of simultaneous sSMC and partial trisomy of chromosome 2q have been rarely described. We report the case of a...

Full description

Saved in:
Bibliographic Details
Published in:Molecular cytogenetics 2015-02, Vol.8 (1), p.10-10, Article 10
Main Authors: Ma, Ruiyu, Peng, Ying, Zhang, Yanghui, Xia, Yan, Tang, Guizhi, Chang, Jiazhen, Guo, Ruolan, Gui, Baoheng, Huang, Yanru, Chen, Chen, Liang, Desheng, Wu, Lingqian
Format: Article
Language:English
Subjects:
Case Report
Case studies
Chromosomes
Genetic aspects
Genetic research
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Increasing number of cases with small supernumerary marker chromosomes (sSMCs) without centromeric DNA and dozens of cases with trisomy 2q3 have been reported in recent years. However, cases of simultaneous sSMC and partial trisomy of chromosome 2q have been rarely described. We report the case of a young girl patient with growth retardation and mild facial features due to a partial trisomy 2q33.3-37.3. The 34.3 Mb-duplication of the 2q33.3 to q37.3 region found in the patient constituted a supernumerary inverted duplicated neocentric marker chromosome. This is the first case of a patient with partial trisomy 2q33.3-37.3 presenting an inverted duplicated neocentric marker chromosome. Based on the case, this study will help further understanding the genotype/phenotype correlations of partial 2q3 duplication and exploring the relationship between neocentric sSMC and human diseases.
ISSN:1755-8166
1755-8166
DOI:10.1186/s13039-015-0111-1