Steroids as an adjunct for reducing the incidence of proliferative vitreoretinopathy after rhegmatogenous retinal detachment surgery: a systematic review and meta-analysis

This meta-analysis was performed to determine the effectiveness of steroids as an adjunct following rhegmatogenous retinal detachment (RRD) surgery. RRD patients with or without proliferative vitreoretinopathy (PVR) were included. The treatment group included patients in whom steroids were used as a...

Full description

Saved in:
Bibliographic Details
Published in:Drug design, development and therapy development and therapy, 2015-01, Vol.9, p.1393-1400
Main Authors: Shi, Hui, Guo, Tao, Liu, Peng-Cheng, Wang, Qian-Yi, Du, Ya-Ru, Liu, Qing-Yu, He, Meng-Mei, Liu, Jun-Ling, Yu, Jing
Format: Article
Language:English
Subjects:
Acuity
Age
Bias
Care and treatment
Clinical trials
Collaboration
Complications
Confidence intervals
Dosage and administration
Evidence-based medicine
Eye
Heterogeneity
Histamine
Humans
Incidence
Inflammation
Intraocular pressure
Macular degeneration
Management
Meta-analysis
Original Research
Patients
Randomization
Randomized Controlled Trials as Topic
Retina
Retinal detachment
Retinal Detachment - complications
Retinal Detachment - surgery
Statistical analysis
Steroid hormones
Steroids
Steroids (Drugs)
Steroids - administration & dosage
Steroids - pharmacology
Steroids - therapeutic use
Surgery
Systematic review
Visual acuity
Vitreoretinopathy, Proliferative - complications
Vitreoretinopathy, Proliferative - prevention & control
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This meta-analysis was performed to determine the effectiveness of steroids as an adjunct following rhegmatogenous retinal detachment (RRD) surgery. RRD patients with or without proliferative vitreoretinopathy (PVR) were included. The treatment group included patients in whom steroids were used as an adjunct and a control group in which placebo was used. Only randomized controlled trials were included. We searched the main electronic databases and included studies published until July 2014. PVR odds ratio, visual acuity, retinal reattachment rate, and complications were evaluated in three trials. Three randomized controlled trials were included in the meta-analysis. There was no significant difference in the incidence of postoperative PVR between groups (heterogeneity I (2)=48%, P=0.14). However, the incidence of postoperative PVR was lower in the treatment group (I (2)=0%, P
ISSN:1177-8881
1177-8881
DOI:10.2147/DDDT.S80983