Genetic polymorphisms of CYP2D610 and the effectiveness of combined tamoxifen citrate and testosterone undecanoate treatment in infertile men with idiopathic oligozoospermia

Tamoxifen citrate, as the first line of treatment for infertile men with idiopathic oligozoospermia, was proposed by the World Health Organization (WHO), and testosterone undecanoate has shown benefits in semen values. Our objective was to assess the effectiveness of treatment with tamoxifen citrate...

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Bibliographic Details
Published in:Journal of Zhejiang University. B. Science 2015-03, Vol.16 (3), p.191-197
Main Authors: Tang, Kai-fa, Zhao, Yi-li, Ding, Shang-shu, Wu, Qi-fei, Wang, Xing-yang, Shi, Jia-qi, Sun, Fa, Xing, Jun-ping
Format: Article
Language:English
Subjects:
Adult
Amino Acid Substitution
Biomedical and Life Sciences
Biomedicine
Case-Control Studies
Cytochrome P-450 CYP2D6 - genetics
Cytochrome P-450 CYP2D6 - metabolism
Drug Therapy, Combination
Female
Follicle Stimulating Hormone - blood
Gene Frequency
Humans
Luteinizing Hormone - blood
Male
Oligospermia - drug therapy
Oligospermia - enzymology
Oligospermia - genetics
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Pregnancy
Sperm Count
Sperm Motility - drug effects
Tamoxifen - administration & dosage
Testosterone - administration & dosage
Testosterone - analogs & derivatives
Testosterone - blood
Treatment Outcome
Young Adult
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Summary:Tamoxifen citrate, as the first line of treatment for infertile men with idiopathic oligozoospermia, was proposed by the World Health Organization (WHO), and testosterone undecanoate has shown benefits in semen values. Our objective was to assess the effectiveness of treatment with tamoxifen citrate and testosterone undecanoate in infertile men with idiopathic oligozoospermia, and whether the results would be affected by polymerphisms of CYP2D6*10 . A total of 230 infertile men and 147 controls were included in the study. Patients were treated with tamoxifen citrate and testosterone undecanoate. Sex hormone, sperm parameters, and incidence of spontaneous pregnancy were detected. There were no significant differences between the control and patient groups with respect to CYP2D6*10 genotype frequencies ( P >0.05). The follicle-stimulation hormone (FSH), luteinizing hormone (LH), and testosterone (T) levels were raised, and sperm concentration and motility were increased at 3 months and became significant at 6 months, and they were higher in the wild-type allele (C/C) than in the heterozygous variant allele (C/T) or homozygous variant allele (T/T) subgroups ( P
ISSN:1673-1581
1862-1783
DOI:10.1631/jzus.B1400282