In vitro antibiotic susceptibilities of Yersinia pestis determined by broth microdilution following CLSI methods

In vitro susceptibilities to 45 antibiotics were determined for 30 genetically and geographically diverse strains of Yersinia pestis by the broth microdilution method at two temperatures, 28°C and 35°C, following Clinical and Laboratory Standards Institute (CLSI) methods. The Y. pestis strains demon...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2015-04, Vol.59 (4), p.1919-1921
Main Authors: Heine, Henry S, Hershfield, Jeremy, Marchand, Charles, Miller, Lynda, Halasohoris, Stephanie, Purcell, Bret K, Worsham, Patricia L
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Anti-Bacterial Agents - pharmacology
Colony Count, Microbial
Drug Resistance, Bacterial
Humans
Microbial Sensitivity Tests - methods
Microbial Sensitivity Tests - standards
Plague - microbiology
Susceptibility
Temperature
Yersinia pestis
Yersinia pestis - drug effects
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Summary:In vitro susceptibilities to 45 antibiotics were determined for 30 genetically and geographically diverse strains of Yersinia pestis by the broth microdilution method at two temperatures, 28°C and 35°C, following Clinical and Laboratory Standards Institute (CLSI) methods. The Y. pestis strains demonstrated susceptibility to aminoglycosides, quinolones, tetracyclines, β-lactams, cephalosporins, and carbapenems. Only a 1-well shift was observed for the majority of antibiotics between the two temperatures. Establishing and comparing antibiotic susceptibilities of a diverse but specific set of Y. pestis strains by standardized methods and establishing population ranges and MIC50 and MIC90 values provide reference information for assessing new antibiotic agents and also provide a baseline for use in monitoring any future emergence of resistance.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.04548-14