The gap junction blocker carbenoxolone enhances propofol and sevoflurane-induced loss of consciousness

General anesthetics induce loss of consciousness by inhibiting ascending arousal pathways, and they interfere with gap junction electrical coupling. The present study aimed to determine whether inhibition of gap junction-mediated signaling could influence general anesthetic-induced loss of conscious...

Full description

Saved in:
Bibliographic Details
Published in:Neural regeneration research 2012-03, Vol.7 (7), p.492-495
Main Authors: Liu, Zhigang, Liu, Yongfang, Zhao, Bo, Du, Li, Xia, Zhongyuan, Chen, Xiangdong, Luo, Tao
Format: Article
Language:English
Subjects:
Anesthesia
Consciousness
Experiments
Fainting
Laboratory animals
Nervous system
Research and Report : Neurogenesis and Neural Plasticity
Rodents
Studies
Surgery
七氟醚
侧脑室注射
全身麻醉
异丙酚
电耦合干扰
缝隙连接
诱导
阻断剂
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:General anesthetics induce loss of consciousness by inhibiting ascending arousal pathways, and they interfere with gap junction electrical coupling. The present study aimed to determine whether inhibition of gap junction-mediated signaling could influence general anesthetic-induced loss of consciousness. The general anesthetics sevoflurane and propofol were used. Intracerebroventricular administration of carbenoxolone, a gap junction blocker, significantly decreased the time to loss of the righting reflex （P 0.05）, but prolonged the time to recovery of the reflex （P 0.05）. Moreover, intracerebroventricular administration of carbenoxolone increased the sensitivity to sevoflurane, with a leftward shift of the loss of righting reflex dose-response curve, and decreased the 50% effective concentration of sevoflurane. These results suggest that the gap junction blocker carbenoxolone enhances propofol and sevoflurane-mediated general anesthesia.
ISSN:1673-5374
1876-7958
DOI:10.3969/j.issn.1673-5374.2012.07.002