CD4+ T cell recovery during suppression of HIV replication: an international comparison of the immunological efficacy of antiretroviral therapy in North America, Asia and Africa

Background: Even among HIV-infected patients who fully suppress plasma HIV RNA replication on antiretroviral therapy, genetic (e.g. CCL3L1 copy number), viral (e.g. tropism) and environmental (e.g. chronic exposure to microbial antigens) factors influence CD4 recovery. These factors differ markedly...

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Published in:International journal of epidemiology 2015-02, Vol.44 (1), p.251-263
Main Authors: Geng, Elvin H, Neilands, Torsten B, Thièbaut, Rodolphe, Bosco Bwana, Mwebesa, Nash, Denis, Moore, Richard D, Wood, Robin, Marcel Zannou, Djimon, Althoff, Keri N, Lian Lim, Poh, Nachega, Jean B, Easterbrook, Philippa J, Kambugu, Andrew, Little, Francesca, Nakigozi, Gertrude, Nakanjako, Damalie, Kiggundu, Valerian, Chung Ki Li, Patrick, Bangsberg, David R, Fox, Matthew P, Prozesky, Hans W, Hunt, Peter W, Davies, Mary-Ann, Reynolds, Steven J, Egger, Matthias, Yiannoutsos, Constantin T, Vittinghoff, Eric V, Deeks, Steven G, Martin, Jeffrey N
Format: Article
Language:English
Subjects:
Human immunodeficiency virus
Miscellaneous
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Summary:Background: Even among HIV-infected patients who fully suppress plasma HIV RNA replication on antiretroviral therapy, genetic (e.g. CCL3L1 copy number), viral (e.g. tropism) and environmental (e.g. chronic exposure to microbial antigens) factors influence CD4 recovery. These factors differ markedly around the world and therefore the expected CD4 recovery during HIV RNA suppression may differ globally.Methods: We evaluated HIV-infected adults from North America, West Africa, East Africa, Southern Africa and Asia starting non-nucleoside reverse transcriptase inhibitor-based regimens containing efavirenz or nevirapine, who achieved at least one HIV RNA level
ISSN:0300-5771
1464-3685
DOI:10.1093/ije/dyu271