Sensing of Mycobacterium tuberculosis and consequences to both host and bacillus

Summary Mycobacterium tuberculosis (Mtb), the primary causative agent of human tuberculosis, has killed more people than any other bacterial pathogen in human history and remains one of the most important transmissible diseases worldwide. Because of the long‐standing interaction of Mtb with humans,...

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Bibliographic Details
Published in:Immunological reviews 2015-03, Vol.264 (1), p.204-219
Main Authors: Stamm, Chelsea E., Collins, Angela C., Shiloh, Michael U.
Format: Article
Language:English
Subjects:
Animals
Antigen Presentation - immunology
Antigens, Bacterial - immunology
Antigens, Bacterial - metabolism
Host-Pathogen Interactions - immunology
Humans
Immunity, Innate
innate immunity
Lectins, C-Type - metabolism
microbial pathogenesis
Mycobacterium tuberculosis
Mycobacterium tuberculosis - immunology
pattern recognition receptors
Protein Binding
Receptors, Immunologic - metabolism
Receptors, Pattern Recognition - metabolism
Receptors, Scavenger - metabolism
Toll-Like Receptors - metabolism
Tuberculosis - immunology
Tuberculosis - metabolism
Tuberculosis - microbiology
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Summary:Summary Mycobacterium tuberculosis (Mtb), the primary causative agent of human tuberculosis, has killed more people than any other bacterial pathogen in human history and remains one of the most important transmissible diseases worldwide. Because of the long‐standing interaction of Mtb with humans, it is no surprise that human mucosal and innate immune cells have evolved multiple mechanisms to detect Mtb during initial contact. To that end, the cell surface of human cells is decorated with numerous pattern recognition receptors for a variety of mycobacterial ligands. Furthermore, once Mtb is ingested into professional phagocytes, other host molecules are engaged to report on the presence of an intracellular pathogen. In this review, we discuss the role of specific mycobacterial products in modulating the host's ability to detect Mtb. In addition, we describe the specific host receptors that mediate the detection of mycobacterial infection and the role of individual receptors in mycobacterial pathogenesis in humans and model organisms.
ISSN:0105-2896
1600-065X
DOI:10.1111/imr.12263