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HOX-7 suppresses body weight gain and adipogenesis-related gene expression in high-fat-diet-induced obese mice
HOX-7 is a newly developed dietary formula composed of traditional oriental herbal medicines. The formula was developed with the aim of improving weight control. We investigated the anti-obesity effect of HOX-7 on high-fat-diet (HFD)-induced obesity in C57BL/6 mice. The mice were divided into four g...
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| Published in: | BMC complementary and alternative medicine 2014-12, Vol.14 (1), p.505-505, Article 505 |
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| creator | Lee, Heon-Myung Rim, Hong-Kun Seo, Jong-Hwan Kook, Yoon-Bum Kim, Sung-Kew Oh, Chang-Hyun Yoo, Kyung Ho Jin, Jong-Sik An, Hyo-Jin |
| description | HOX-7 is a newly developed dietary formula composed of traditional oriental herbal medicines. The formula was developed with the aim of improving weight control. We investigated the anti-obesity effect of HOX-7 on high-fat-diet (HFD)-induced obesity in C57BL/6 mice.
The mice were divided into four groups and were fed a normal diet (ND), HFD, or HFD with oral administration of HOX-7 at 100 or 200 mg/kg/day for 12 weeks. Body and fat weight, histological changes of fat tissue, and the expression of key adipogenic transcription factors were investigated.
The body weight of mice fed the HFD with HOX-7 was significantly decreased compared to the HFD group. There were no obvious differences in weekly food intake among the 4 groups. The weight of the epididymal and total fat pads was reduced in mice fed the HFD with HOX-7. Treatment with HOX-7 also substantially attenuated the expression of key adipogenic transcription factors, including peroxisome proliferator-activated receptor γ, CCAAT/enhancer binding protein α, sterol regulatory element binding protein 1c, adipocyte P2, liver X receptor, and lipoprotein lipase in the epididymal adipose tissue.
Overall, this study highlighted the anti-obesity effects of HOX-7, a finding that could contribute to the development of natural anti-obesity herbal medicines. |
| doi_str_mv | 10.1186/1472-6882-14-505 |
| format | article |
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The mice were divided into four groups and were fed a normal diet (ND), HFD, or HFD with oral administration of HOX-7 at 100 or 200 mg/kg/day for 12 weeks. Body and fat weight, histological changes of fat tissue, and the expression of key adipogenic transcription factors were investigated.
The body weight of mice fed the HFD with HOX-7 was significantly decreased compared to the HFD group. There were no obvious differences in weekly food intake among the 4 groups. The weight of the epididymal and total fat pads was reduced in mice fed the HFD with HOX-7. Treatment with HOX-7 also substantially attenuated the expression of key adipogenic transcription factors, including peroxisome proliferator-activated receptor γ, CCAAT/enhancer binding protein α, sterol regulatory element binding protein 1c, adipocyte P2, liver X receptor, and lipoprotein lipase in the epididymal adipose tissue.
Overall, this study highlighted the anti-obesity effects of HOX-7, a finding that could contribute to the development of natural anti-obesity herbal medicines.</description><identifier>ISSN: 1472-6882</identifier><identifier>EISSN: 1472-6882</identifier><identifier>DOI: 10.1186/1472-6882-14-505</identifier><identifier>PMID: 25515293</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adipocytes - drug effects ; Adipogenesis - drug effects ; Adipogenesis - genetics ; Adipose Tissue - cytology ; Adipose Tissue - metabolism ; Animals ; Anti-Obesity Agents - pharmacology ; Anti-Obesity Agents - therapeutic use ; Care and treatment ; CCAAT-Enhancer-Binding Protein-alpha - genetics ; CCAAT-Enhancer-Binding Protein-alpha - metabolism ; Diet, High-Fat - adverse effects ; DNA binding proteins ; Eating - drug effects ; Fatty acids ; Gene Expression - drug effects ; Health aspects ; Magnoliopsida ; Male ; Medicine, East Asian Traditional ; Metabolic disorders ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Obesity ; Obesity - etiology ; Obesity - genetics ; Obesity - metabolism ; Obesity - prevention & control ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; PPAR gamma - metabolism ; Studies ; Transcription Factors - metabolism ; Type 2 diabetes ; Weight Gain - drug effects ; Weight Loss - drug effects</subject><ispartof>BMC complementary and alternative medicine, 2014-12, Vol.14 (1), p.505-505, Article 505</ispartof><rights>COPYRIGHT 2014 BioMed Central Ltd.</rights><rights>2014 Lee et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>Lee et al.; licensee BioMed Central. 2014</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b615t-5e578e454ea8068980de1276ec5114f3bd845633e50fc4670a71c2e87e67c4273</citedby><cites>FETCH-LOGICAL-b615t-5e578e454ea8068980de1276ec5114f3bd845633e50fc4670a71c2e87e67c4273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320579/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320579/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25515293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Heon-Myung</creatorcontrib><creatorcontrib>Rim, Hong-Kun</creatorcontrib><creatorcontrib>Seo, Jong-Hwan</creatorcontrib><creatorcontrib>Kook, Yoon-Bum</creatorcontrib><creatorcontrib>Kim, Sung-Kew</creatorcontrib><creatorcontrib>Oh, Chang-Hyun</creatorcontrib><creatorcontrib>Yoo, Kyung Ho</creatorcontrib><creatorcontrib>Jin, Jong-Sik</creatorcontrib><creatorcontrib>An, Hyo-Jin</creatorcontrib><title>HOX-7 suppresses body weight gain and adipogenesis-related gene expression in high-fat-diet-induced obese mice</title><title>BMC complementary and alternative medicine</title><addtitle>BMC Complement Altern Med</addtitle><description>HOX-7 is a newly developed dietary formula composed of traditional oriental herbal medicines. The formula was developed with the aim of improving weight control. We investigated the anti-obesity effect of HOX-7 on high-fat-diet (HFD)-induced obesity in C57BL/6 mice.
The mice were divided into four groups and were fed a normal diet (ND), HFD, or HFD with oral administration of HOX-7 at 100 or 200 mg/kg/day for 12 weeks. Body and fat weight, histological changes of fat tissue, and the expression of key adipogenic transcription factors were investigated.
The body weight of mice fed the HFD with HOX-7 was significantly decreased compared to the HFD group. There were no obvious differences in weekly food intake among the 4 groups. The weight of the epididymal and total fat pads was reduced in mice fed the HFD with HOX-7. Treatment with HOX-7 also substantially attenuated the expression of key adipogenic transcription factors, including peroxisome proliferator-activated receptor γ, CCAAT/enhancer binding protein α, sterol regulatory element binding protein 1c, adipocyte P2, liver X receptor, and lipoprotein lipase in the epididymal adipose tissue.
Overall, this study highlighted the anti-obesity effects of HOX-7, a finding that could contribute to the development of natural anti-obesity herbal medicines.</description><subject>Adipocytes - drug effects</subject><subject>Adipogenesis - drug effects</subject><subject>Adipogenesis - genetics</subject><subject>Adipose Tissue - cytology</subject><subject>Adipose Tissue - metabolism</subject><subject>Animals</subject><subject>Anti-Obesity Agents - pharmacology</subject><subject>Anti-Obesity Agents - therapeutic use</subject><subject>Care and treatment</subject><subject>CCAAT-Enhancer-Binding Protein-alpha - genetics</subject><subject>CCAAT-Enhancer-Binding Protein-alpha - metabolism</subject><subject>Diet, High-Fat - adverse effects</subject><subject>DNA binding proteins</subject><subject>Eating - drug effects</subject><subject>Fatty acids</subject><subject>Gene Expression - drug effects</subject><subject>Health aspects</subject><subject>Magnoliopsida</subject><subject>Male</subject><subject>Medicine, East Asian Traditional</subject><subject>Metabolic disorders</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Obese</subject><subject>Obesity</subject><subject>Obesity - etiology</subject><subject>Obesity - genetics</subject><subject>Obesity - metabolism</subject><subject>Obesity - prevention & control</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>PPAR gamma - metabolism</subject><subject>Studies</subject><subject>Transcription Factors - metabolism</subject><subject>Type 2 diabetes</subject><subject>Weight Gain - drug effects</subject><subject>Weight Loss - drug effects</subject><issn>1472-6882</issn><issn>1472-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqNks2L1TAUxYsozji6dyUFQdxkTJrPtxGGhzrCwGwU3IU0uW0ztEltWnX-e1Pf-HxPRpAskia_c7g99xbFc4LPCVHiDWGyQkKpChGGOOYPitP91cOD80nxJKUbjIlUhD0uTirOCa829LQIl9dfkCzTMo4TpASprKO7Lb-Db7u5bI0PpQmuNM6PsYUAySc0QW9mcOX6XcKPX0IfQ5nZLstQY2bkPMzIB7fYDMYaEpSDt_C0eNSYPsGzu_2s-Pz-3aftJbq6_vBxe3GFakH4jDhwqYBxBkZhoTYKOyCVFGA5IayhtVOMC0qB48YyIbGRxFagJAhpWSXpWfF25zsu9QDOQpgn0-tx8oOZbnU0Xh-_BN_pNn7TjFaYy0022O4Mah__YXD8YuOg17z1mnc-6dyO7PL6rowpfl0gzXrwyULfmwBxSZqIDcs_Rxn-D5RXVAqC19pe_oXexGUKOc9M5dAoYUL8oVrTg_ahiblOu5rqC043ghAqWKbO76HycpD7FQM0Pt8fCV4dCDow_dyl2C9znoB0DOIdaKeY0gTNPjyC9Tq998X14rBre8HvcaU_AROj5_0</recordid><startdate>20141217</startdate><enddate>20141217</enddate><creator>Lee, Heon-Myung</creator><creator>Rim, Hong-Kun</creator><creator>Seo, Jong-Hwan</creator><creator>Kook, Yoon-Bum</creator><creator>Kim, Sung-Kew</creator><creator>Oh, Chang-Hyun</creator><creator>Yoo, Kyung Ho</creator><creator>Jin, Jong-Sik</creator><creator>An, Hyo-Jin</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20141217</creationdate><title>HOX-7 suppresses body weight gain and adipogenesis-related gene expression in high-fat-diet-induced obese mice</title><author>Lee, Heon-Myung ; Rim, Hong-Kun ; Seo, Jong-Hwan ; Kook, Yoon-Bum ; Kim, Sung-Kew ; Oh, Chang-Hyun ; Yoo, Kyung Ho ; Jin, Jong-Sik ; An, Hyo-Jin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b615t-5e578e454ea8068980de1276ec5114f3bd845633e50fc4670a71c2e87e67c4273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adipocytes - drug effects</topic><topic>Adipogenesis - drug effects</topic><topic>Adipogenesis - genetics</topic><topic>Adipose Tissue - cytology</topic><topic>Adipose Tissue - metabolism</topic><topic>Animals</topic><topic>Anti-Obesity Agents - pharmacology</topic><topic>Anti-Obesity Agents - therapeutic use</topic><topic>Care and treatment</topic><topic>CCAAT-Enhancer-Binding Protein-alpha - genetics</topic><topic>CCAAT-Enhancer-Binding Protein-alpha - metabolism</topic><topic>Diet, High-Fat - adverse effects</topic><topic>DNA binding proteins</topic><topic>Eating - drug effects</topic><topic>Fatty acids</topic><topic>Gene Expression - drug effects</topic><topic>Health aspects</topic><topic>Magnoliopsida</topic><topic>Male</topic><topic>Medicine, East Asian Traditional</topic><topic>Metabolic disorders</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Obese</topic><topic>Obesity</topic><topic>Obesity - etiology</topic><topic>Obesity - genetics</topic><topic>Obesity - metabolism</topic><topic>Obesity - prevention & control</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>PPAR gamma - metabolism</topic><topic>Studies</topic><topic>Transcription Factors - metabolism</topic><topic>Type 2 diabetes</topic><topic>Weight Gain - drug effects</topic><topic>Weight Loss - drug effects</topic><toplevel>online_resources</toplevel><creatorcontrib>Lee, Heon-Myung</creatorcontrib><creatorcontrib>Rim, Hong-Kun</creatorcontrib><creatorcontrib>Seo, Jong-Hwan</creatorcontrib><creatorcontrib>Kook, Yoon-Bum</creatorcontrib><creatorcontrib>Kim, Sung-Kew</creatorcontrib><creatorcontrib>Oh, Chang-Hyun</creatorcontrib><creatorcontrib>Yoo, Kyung Ho</creatorcontrib><creatorcontrib>Jin, Jong-Sik</creatorcontrib><creatorcontrib>An, Hyo-Jin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Heon-Myung</au><au>Rim, Hong-Kun</au><au>Seo, Jong-Hwan</au><au>Kook, Yoon-Bum</au><au>Kim, Sung-Kew</au><au>Oh, Chang-Hyun</au><au>Yoo, Kyung Ho</au><au>Jin, Jong-Sik</au><au>An, Hyo-Jin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HOX-7 suppresses body weight gain and adipogenesis-related gene expression in high-fat-diet-induced obese mice</atitle><jtitle>BMC complementary and alternative medicine</jtitle><addtitle>BMC Complement Altern Med</addtitle><date>2014-12-17</date><risdate>2014</risdate><volume>14</volume><issue>1</issue><spage>505</spage><epage>505</epage><pages>505-505</pages><artnum>505</artnum><issn>1472-6882</issn><eissn>1472-6882</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>HOX-7 is a newly developed dietary formula composed of traditional oriental herbal medicines. The formula was developed with the aim of improving weight control. We investigated the anti-obesity effect of HOX-7 on high-fat-diet (HFD)-induced obesity in C57BL/6 mice.
The mice were divided into four groups and were fed a normal diet (ND), HFD, or HFD with oral administration of HOX-7 at 100 or 200 mg/kg/day for 12 weeks. Body and fat weight, histological changes of fat tissue, and the expression of key adipogenic transcription factors were investigated.
The body weight of mice fed the HFD with HOX-7 was significantly decreased compared to the HFD group. There were no obvious differences in weekly food intake among the 4 groups. The weight of the epididymal and total fat pads was reduced in mice fed the HFD with HOX-7. Treatment with HOX-7 also substantially attenuated the expression of key adipogenic transcription factors, including peroxisome proliferator-activated receptor γ, CCAAT/enhancer binding protein α, sterol regulatory element binding protein 1c, adipocyte P2, liver X receptor, and lipoprotein lipase in the epididymal adipose tissue.
Overall, this study highlighted the anti-obesity effects of HOX-7, a finding that could contribute to the development of natural anti-obesity herbal medicines.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>25515293</pmid><doi>10.1186/1472-6882-14-505</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1472-6882 |
| ispartof | BMC complementary and alternative medicine, 2014-12, Vol.14 (1), p.505-505, Article 505 |
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| language | eng |
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| source | Open Access: PubMed Central |
| subjects | Adipocytes - drug effects Adipogenesis - drug effects Adipogenesis - genetics Adipose Tissue - cytology Adipose Tissue - metabolism Animals Anti-Obesity Agents - pharmacology Anti-Obesity Agents - therapeutic use Care and treatment CCAAT-Enhancer-Binding Protein-alpha - genetics CCAAT-Enhancer-Binding Protein-alpha - metabolism Diet, High-Fat - adverse effects DNA binding proteins Eating - drug effects Fatty acids Gene Expression - drug effects Health aspects Magnoliopsida Male Medicine, East Asian Traditional Metabolic disorders Mice Mice, Inbred C57BL Mice, Obese Obesity Obesity - etiology Obesity - genetics Obesity - metabolism Obesity - prevention & control Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use PPAR gamma - metabolism Studies Transcription Factors - metabolism Type 2 diabetes Weight Gain - drug effects Weight Loss - drug effects |
| title | HOX-7 suppresses body weight gain and adipogenesis-related gene expression in high-fat-diet-induced obese mice |
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