HOX-7 suppresses body weight gain and adipogenesis-related gene expression in high-fat-diet-induced obese mice

HOX-7 is a newly developed dietary formula composed of traditional oriental herbal medicines. The formula was developed with the aim of improving weight control. We investigated the anti-obesity effect of HOX-7 on high-fat-diet (HFD)-induced obesity in C57BL/6 mice. The mice were divided into four g...

Full description

Saved in:
Bibliographic Details
Published in:BMC complementary and alternative medicine 2014-12, Vol.14 (1), p.505-505, Article 505
Main Authors: Lee, Heon-Myung, Rim, Hong-Kun, Seo, Jong-Hwan, Kook, Yoon-Bum, Kim, Sung-Kew, Oh, Chang-Hyun, Yoo, Kyung Ho, Jin, Jong-Sik, An, Hyo-Jin
Format: Article
Language:English
Subjects:
Adipocytes - drug effects
Adipogenesis - drug effects
Adipogenesis - genetics
Adipose Tissue - cytology
Adipose Tissue - metabolism
Animals
Anti-Obesity Agents - pharmacology
Anti-Obesity Agents - therapeutic use
Care and treatment
CCAAT-Enhancer-Binding Protein-alpha - genetics
CCAAT-Enhancer-Binding Protein-alpha - metabolism
Diet, High-Fat - adverse effects
DNA binding proteins
Eating - drug effects
Fatty acids
Gene Expression - drug effects
Health aspects
Magnoliopsida
Male
Medicine, East Asian Traditional
Metabolic disorders
Mice
Mice, Inbred C57BL
Mice, Obese
Obesity
Obesity - etiology
Obesity - genetics
Obesity - metabolism
Obesity - prevention & control
Phytotherapy
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
PPAR gamma - metabolism
Studies
Transcription Factors - metabolism
Type 2 diabetes
Weight Gain - drug effects
Weight Loss - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:HOX-7 is a newly developed dietary formula composed of traditional oriental herbal medicines. The formula was developed with the aim of improving weight control. We investigated the anti-obesity effect of HOX-7 on high-fat-diet (HFD)-induced obesity in C57BL/6 mice. The mice were divided into four groups and were fed a normal diet (ND), HFD, or HFD with oral administration of HOX-7 at 100 or 200 mg/kg/day for 12 weeks. Body and fat weight, histological changes of fat tissue, and the expression of key adipogenic transcription factors were investigated. The body weight of mice fed the HFD with HOX-7 was significantly decreased compared to the HFD group. There were no obvious differences in weekly food intake among the 4 groups. The weight of the epididymal and total fat pads was reduced in mice fed the HFD with HOX-7. Treatment with HOX-7 also substantially attenuated the expression of key adipogenic transcription factors, including peroxisome proliferator-activated receptor γ, CCAAT/enhancer binding protein α, sterol regulatory element binding protein 1c, adipocyte P2, liver X receptor, and lipoprotein lipase in the epididymal adipose tissue. Overall, this study highlighted the anti-obesity effects of HOX-7, a finding that could contribute to the development of natural anti-obesity herbal medicines.
ISSN:1472-6882
1472-6882
DOI:10.1186/1472-6882-14-505