Biological roles of CCAAT/Enhancer-binding protein delta during inflammation

CCAAT/enhancer-binding protein delta (CEBPD) belongs to the CCAAT/enhancer-binding protein family, and these proteins function as transcription factors in many biological processes, including cell differentiation, motility, growth arrest, proliferation, cell death, metabolism and immune responses. T...

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Bibliographic Details
Published in:Journal of biomedical science 2015-01, Vol.22 (1), p.6-6, Article 6
Main Authors: Ko, Chiung-Yuan, Chang, Wen-Chang, Wang, Ju-Ming
Format: Article
Language:English
Subjects:
CCAAT-Enhancer-Binding Protein-delta - genetics
CCAAT-Enhancer-Binding Protein-delta - metabolism
Cell death
DNA binding proteins
Gene Expression Regulation
Genes
Humans
Immune response
Inflammation
Inflammation - genetics
Inflammation - metabolism
Physiological aspects
Protein binding
Review
Type 2 diabetes
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Summary:CCAAT/enhancer-binding protein delta (CEBPD) belongs to the CCAAT/enhancer-binding protein family, and these proteins function as transcription factors in many biological processes, including cell differentiation, motility, growth arrest, proliferation, cell death, metabolism and immune responses. The functional diversity of CEBPD depends, in part, on the cell type and cellular context, which indicates that CEBPD could interpret a variety of cues to adjust cellular responses in specific situations. Here, we review the regulation of the CEBPD gene and its function in response to inflammatory stimuli. We also address its effects in inflammation-related diseases through a discussion of its recently discovered downstream targets. Regarding to the previous discoveries and new insights in inflammation-associated diseases, suggesting CEBPD could also be a central gene in inflammation. Importantly, the results of this study indicate that the investigation of CEBPD could open a new avenue to help better understand the inflammatory response.
ISSN:1423-0127
1021-7770
1423-0127
DOI:10.1186/s12929-014-0110-2