Partial Amino-Acid Sequences of Human and Rabbit C-Reactive Proteins: Homology with Immunoglobulins and Histocompatibility Antigens

Partial amino-acid sequence analyses of the amino terminus of rabbit C-reactive protein and of a peptide isolated from human C-reactive protein after cyanogen bromide cleavage show an extensive sequence homology between these proteins. Computer analysis detected a distant but significant homology be...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1977-03, Vol.74 (3), p.1214-1218
Main Authors: Osmand, Alexander P., Gewurz, Henry, Friedenson, Bernard
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Antigens
Biochemistry
Biological Evolution
C-Reactive Protein
Gels
Histocompatibility Antigens
HLA Antigens
Humans
Immunoglobulin constant regions
Immunoglobulin Fc Fragments
Immunoglobulin gamma-Chains
Immunoglobulin M
Immunoglobulins
Models, Biological
Rabbits
Transplantation immunology
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Summary:Partial amino-acid sequence analyses of the amino terminus of rabbit C-reactive protein and of a peptide isolated from human C-reactive protein after cyanogen bromide cleavage show an extensive sequence homology between these proteins. Computer analysis detected a distant but significant homology between rabbit C-reactive protein and the CH3 domain of human IgG. In addition, an examination of the limited data available for the amino-acid sequences of human and mouse histocompatibility antigens revealed a similarity between these proteins and C-reactive protein and, therefore, immunoglobulins. These relationships are presented as evidence in support of the hypothesis that C-reactive protein and immunoglobulins share, in addition to functional similarities, a common evolutionary origin with the major histocompatibility antigens.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.74.3.1214