Impact of enteral nutrition on energy metabolism in patients with Crohn’s disease

AIM: To investigate the impact of enteral nutrition(EN) on the body composition and metabolism in patientswith Crohn’s disease(CD). METHODS: Sixty-one patients diagnosed with CD were enrolled in this study. They were given only EN(enteral nutritional suspension, TPF, non-elemental diet) support for...

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Published in:World journal of gastroenterology : WJG 2015-01, Vol.21 (4), p.1299-1304
Main Authors: Zhao, Jie, Dong, Jian-Ning, Gong, Jian-Feng, Wang, Hong-Gang, Li, Yi, Zhang, Liang, Zuo, Lu-Gen, Feng, Yun, Gu, Li-Li, Li, Ning, Li, Jie-Shou, Zhu, Wei-Ming
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Body Composition
China
composition
Crohn Disease - diagnosis
Crohn Disease - metabolism
Crohn Disease - physiopathology
Crohn Disease - therapy
Crohn’s
disease
Enteral
Energy Metabolism
Enteral Nutrition
Female
Humans
Inflammation Mediators - blood
Male
Middle Aged
nutrition
Body
Prospective Studies
Prospective Study
Time Factors
Treatment Outcome
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Summary:AIM: To investigate the impact of enteral nutrition(EN) on the body composition and metabolism in patientswith Crohn’s disease(CD). METHODS: Sixty-one patients diagnosed with CD were enrolled in this study. They were given only EN(enteral nutritional suspension, TPF, non-elemental diet) support for 4 wk, without any treatment with corticosteroids, immunosuppressive drugs, infliximab or by surgical operation. Body composition statistics such as weight, body mass index, skeletal muscle mass(SMM), fat mass, protein mass and inflammation indexes such as C-reactive protein(CRP), erythrocyte sedimentation rate(ESR) and CD activity index(CDAI) were recorded before and after EN support. RESULTS: The 61 patients were divided into three groups according to CDAI before and after EN support: A(active phase into remission via EN, n = 21), B(remained in active phase before and after EN, n = 19) and C(in remission before and after EN, n = 21). Patients in group A had a significant increase in SMM(22.11 ± 4.77 kg vs 23.23 ± 4.49 kg, P = 0.044), protein mass(8.01 ± 1.57 kg vs 8.44 ± 1.45 kg, P = 0.019) and decrease in resting energy expenditure(REE) per kilogram(27.42 ± 5.01 kcal/kg per day vs 22.62 ± 5.45 kcal/kg per day, P < 0.05). There was no significant difference between predicted and measured REE in active CD patients according to the HarrisBenedict equation. There was no linear correlation between the measured REE and CRP, ESR or CDAI in active CD patients. CONCLUSION: EN could decrease the hypermetabolism in active CD patients by reducing the inflammatory response.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v21.i4.1299