Effect of omeprazole on symptoms and ultrastructural esophageal damage in acid bile reflux

AIM: To value whether omeprazole could induce the healing of DIS and regression of symptoms in patientswith DGER. METHODS: We enrolled 15 symptomatic patients with a pathological esophageal 24-h pH-metry and bilimetry. Patients underwent endoscopy and biopsies were taken from the distal esophagus. S...

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Published in:World journal of gastroenterology : WJG 2005-03, Vol.11 (12), p.1876-1880
Main Author: CarloCalabrese AnnaFabbri MauroBortolotti, GiovannaCenacchi ScialpiCarlo DesireeZahlane MarioMiglioli GiulioDiFebo
Format: Article
Language:English
Subjects:
Adult
Anti-Ulcer Agents - administration & dosage
Brief Reports
Epithelial Cells - drug effects
Epithelial Cells - pathology
Epithelial Cells - ultrastructure
Esophagitis, Peptic - drug therapy
Esophagitis, Peptic - pathology
Esophagus - drug effects
Esophagus - pathology
Esophagus - ultrastructure
Female
Humans
Male
Microscopy, Electron, Transmission
Middle Aged
Mucous Membrane - drug effects
Mucous Membrane - pathology
Mucous Membrane - ultrastructure
Omeprazole - administration & dosage
奥美拉唑
胆汁逆流
药物治疗
食道损伤
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Summary:AIM: To value whether omeprazole could induce the healing of DIS and regression of symptoms in patientswith DGER. METHODS: We enrolled 15 symptomatic patients with a pathological esophageal 24-h pH-metry and bilimetry. Patients underwent endoscopy and biopsies were taken from the distal esophagus. Specimens were analyzed at histology and transmission electron microscopy (TFM). Patients were treated with omeprazole 40 mg/d for 3 mo and then endoscopy with biopsies was repeated. Patients with persistent heartburn and/or with an incomplete recovery of DIS were treated for 3 more months and endoscopy with biopsies was performed. RESULTS: Nine patients had a non-erosive reflux disease at endoscopy (NERD) while 6 had erosive esophagitis (ERE)). At histology, of the 6 patients with erosive esophagitis, 5 had mild esophagitis and 1 moderate esophagitis. No patients with NERD showed histological signs of esophagitis. After 3 mo of therapy, 13/15 patients (86.7%, P
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v11.i12.1876