Serum chromogranin-A in hepatocellular carcinoma： Diagnostic utility and limits

AIM: The utility of serum alpha-fetoprotein (α-FP) for the detection of hepatocellular carcinoma (HCC) is questionable. High serum levels of chromogranin-A (CgA) have recentl ybeen reported in HCC. Impaired hepatic, renal, and heart functions influence circulating CgA. The aim of this study was to a...

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Published in:World journal of gastroenterology : WJG 2005-04, Vol.11 (13), p.1987-1990
Main Authors: Spadaro, Aldo, Ajello, Antonino, Morace, Carmela, Zirilli, Agata, D'arrigo, Graziella, Luigiano, Carmelo, Martino, Francesco, Bene, Anna, Migliorato, Domenico, Turiano, Santi, Ferraù, Oscar, Freni, Maria-Antonietta
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers - blood
Brief Reports
Carcinoma, Hepatocellular - blood
Carcinoma, Hepatocellular - diagnosis
Chromogranin A
Chromogranins - blood
Female
Hepatitis, Chronic - blood
Hepatitis, Chronic - diagnosis
Humans
Liver Cirrhosis - blood
Liver Cirrhosis - diagnosis
Liver Neoplasms - blood
Liver Neoplasms - diagnosis
Male
Sensitivity and Specificity
嗜铬粒蛋白-A
肝细胞癌
诊断方法
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Summary:AIM: The utility of serum alpha-fetoprotein (α-FP) for the detection of hepatocellular carcinoma (HCC) is questionable. High serum levels of chromogranin-A (CgA) have recentl ybeen reported in HCC. Impaired hepatic, renal, and heart functions influence circulating CgA. The aim of this study was to assess sensitivity and specificity of serum CgA as a marker of HCC in patients with liver cirrhosis (LC). METHODS: Serum CgA levels were measured by RIA in 339 patients of which 54 HCC, 132 LC, 45 chronic hepatitis (CH), 27 chronic heart failure (CHF), 36 chronic renal failure (CRF), 45 chronic inflammatory bowel disease (IBD) as disease controls and in 75 healthy controls. Patients with liver disease or IBD and concomitant renal and/or heart failure were excluded. Pearson correlation, nonparametric combination test and confidence interval analysis were used for statistical analysis. RESULTS: Serum CgA above normal values (100 ng/mL) were found in 83% of HCC patients, in 48% of LC patients, in 20% of CH patients, in 33% of IBD patients, in 92% of CRF patients, in 100% of CHF patients, and in non eof the healthy controls. The mean CgA values in HCC (769±046), in LC (249±369), in CH (87±94), in CRF(1 390±1 401), in CHF (577±539), in IBD (146±287) were significantly higher than those in healthy controls (48±18). HCC patients had higher CgA values (P200 ng/mL in 21% of the HCC patients and in none of the LC patients. No significant correlation was found between α-FP and CgA in patients with HCC and in patients with cirrhosis. CONCLUSION: When HCC is suspected and α-FP is normalor
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v11.i13.1987