Trends in central nervous system tumor incidence relative to other common cancers in adults, adolescents, and children in the United States, 2000 to 2010

BACKGROUND Time trends in cancer incidence rates (IR) are important to measure the changing burden of cancer on a population over time. The overall IR of cancer in the United States is declining. Although central nervous system tumors (CNST) are rare, they contribute disproportionately to mortality...

Full description

Saved in:
Bibliographic Details
Published in:Cancer 2015-01, Vol.121 (1), p.102-112
Main Authors: Gittleman, Haley R., Ostrom, Quinn T., Rouse, Chaturia D., Dowling, Jacqueline A., de Blank, Peter M., Kruchko, Carol A., Elder, J. Bradley, Rosenfeld, Steven S., Selman, Warren R., Sloan, Andrew E., Barnholtz‐Sloan, Jill S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
annual percent change (APC)
Central Brain Tumor Registry of the United States (CBTRUS)
Central Nervous System Neoplasms - epidemiology
Central Nervous System Neoplasms - ethnology
central nervous system tumors
Child
Child, Preschool
Cluster Analysis
Cohort Studies
Female
Humans
incidence rates
Male
Middle Aged
Neoplasms - epidemiology
Neoplasms - ethnology
Original
SEER Program
Time Factors
time trends
United States - epidemiology
United States - ethnology
United States Cancer Statistics (USCS)
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND Time trends in cancer incidence rates (IR) are important to measure the changing burden of cancer on a population over time. The overall IR of cancer in the United States is declining. Although central nervous system tumors (CNST) are rare, they contribute disproportionately to mortality and morbidity. In this analysis, the authors examined trends in the incidence of the most common cancers and CNST between 2000 and 2010. METHODS The current analysis used data from the United States Cancer Statistics publication and the Central Brain Tumor Registry of the United States. Age‐adjusted IR per 100,000 population with 95% confidence intervals and the annual percent change (APC) with 95% confidence intervals were calculated for selected common cancers and CNST overall and by age, sex, race/ethnicity, selected histologies, and malignancy status. RESULTS In adults, there were significant decreases in colon (2000‐2010: APC, −3.1), breast (2000‐2010: APC, −0.8), lung (2000‐2010: APC, −1.1), and prostate (2000‐2010: APC, −2.4) cancer as well as malignant CNST (2008‐2010: APC, −3.1), but a significant increase was noted in nonmalignant CNST (2004‐2010: APC, 2.7). In adolescents, there were significant increases in malignant CNST (2000‐2008: APC, 1.0) and nonmalignant CNST (2004‐2010: APC, 3.9). In children, there were significant increases in acute lymphocytic leukemia (2000‐2010: APC, 1.0), non‐Hodgkin lymphoma (2000‐2010: APC, 0.6), and malignant CNST (2000‐2010: APC, 0.6). CONCLUSIONS Surveillance of IR trends is an important way to measure the changing public health and economic burden of cancer. In the current study, there were significant decreases noted in the incidence of adult cancer, whereas adolescent and childhood cancer IR were either stable or increasing. Cancer 2015;121:102–112. © 2014 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. Time trends in cancer incidence rates are important to measure the changing burden of cancer on a population over time. In adults, there were significant decreases noted in the incidence of colon, breast, lung, prostate, and malignant central nervous system tumors (CNST), but a significant increase in nonmalignant CNST. There were significant increases observed in malignant CNST and nonmalignant CNST among adolescents and significant increases in acute lymphocytic leukemia, non‐Hodgkin lymphoma, and malignant CNST noted in children.
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.29015