TRP channels and STIM/ORAI proteins: sensors and effectors of cancer and stroma cell migration

Cancer cells are strongly influenced by host cells within the tumour stroma and vice versa. This leads to the development of a tumour microenvironment with distinct physical and chemical properties that are permissive for tumour progression. The ability to migrate plays a central role in this mutual...

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Bibliographic Details
Published in:British journal of pharmacology 2014-12, Vol.171 (24), p.5524-5540
Main Authors: Nielsen, N, Lindemann, O, Schwab, A
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Calcium - metabolism
Calcium Channels - metabolism
Calcium signalling
Cancer
Cell adhesion & migration
Cell migration
Cell Movement - physiology
Cytokines - metabolism
Cytoskeleton
Cytoskeleton - metabolism
Extracellular matrix
Humans
Hypoxia
Intercellular Signaling Peptides and Proteins - metabolism
Membrane Proteins - metabolism
Metastases
Neoplasm Metastasis
Neoplasm Proteins - metabolism
ORAI1 Protein
Oxidative stress
Proteins
Signal Transduction - physiology
Stromal cells
Stromal Cells - metabolism
Stromal Cells - physiology
Stromal Interaction Molecule 1
Themed Section: Cytoskeleton, Extracellular Matrix, Cell Migration, Wound Healing and Related Topics
Transient Receptor Potential Channels - metabolism
Transient receptor potential proteins
Tumor microenvironment
Tumor Microenvironment - physiology
Tumors
Wound healing
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Summary:Cancer cells are strongly influenced by host cells within the tumour stroma and vice versa. This leads to the development of a tumour microenvironment with distinct physical and chemical properties that are permissive for tumour progression. The ability to migrate plays a central role in this mutual interaction. Migration of cancer cells is considered as a prerequisite for tumour metastasis and the migration of host stromal cells is required for reaching the tumour site. Increasing evidence suggests that transient receptor potential (TRP) channels and STIM/ORAI proteins affect key calcium‐dependent mechanisms implicated in both cancer and stroma cell migration. These include, among others, cytoskeletal remodelling, growth factor/cytokine signalling and production, and adaptation to tumour microenvironmental properties such as hypoxia and oxidative stress. In this review, we will summarize the current knowledge regarding TRP channels and STIM/ORAI proteins in cancer and stroma cell migration. We focus on how TRP channel or STIM/ORAI‐mediated Ca2+ signalling directly or indirectly influences cancer and stroma cell migration by affecting the above listed mechanisms. Linked Articles This article is part of a themed section on Cytoskeleton, Extracellular Matrix, Cell Migration, Wound Healing and Related Topics. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue‐24
ISSN:0007-1188
1476-5381
DOI:10.1111/bph.12721