A microfluidic device to study cancer metastasis under chronic and intermittent hypoxia

Metastatic cancer cells must traverse a microenvironment ranging from extremely hypoxic, within the tumor, to highly oxygenated, within the host's vasculature. Tumor hypoxia can be further characterized by regions of both chronic and intermittent hypoxia. We present the design and characterizat...

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Bibliographic Details
Published in:Biomicrofluidics 2014-09, Vol.8 (5), p.054117-054117
Main Authors: Acosta, Miguel A, Jiang, Xiao, Huang, Pin-Kang, Cutler, Kyle B, Grant, Christine S, Walker, Glenn M, Gamcsik, Michael P
Format: Article
Language:English
Subjects:
Cancer
Cell adhesion & migration
Hypoxia
Oxygenation
Regular
Tumors
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Summary:Metastatic cancer cells must traverse a microenvironment ranging from extremely hypoxic, within the tumor, to highly oxygenated, within the host's vasculature. Tumor hypoxia can be further characterized by regions of both chronic and intermittent hypoxia. We present the design and characterization of a microfluidic device that can simultaneously mimic the oxygenation conditions observed within the tumor and model the cell migration and intravasation processes. This device can generate spatial oxygen gradients of chronic hypoxia and produce dynamically changing hypoxic microenvironments in long-term culture of cancer cells.
ISSN:1932-1058
1932-1058
DOI:10.1063/1.4898788