GraSP: Geodesic Graph-based Segmentation with Shape Priors for the functional parcellation of the cortex

Resting-state functional MRI is a powerful technique for mapping the functional organization of the human brain. However, for many types of connectivity analysis, high-resolution voxelwise analyses are computationally infeasible and dimensionality reduction is typically used to limit the number of n...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2015-02, Vol.106, p.207-221
Main Authors: Honnorat, N., Eavani, H., Satterthwaite, T.D., Gur, R.E., Gur, R.C., Davatzikos, C.
Format: Article
Language:English
Subjects:
Age
Algorithms
Cerebral Cortex - anatomy & histology
Cerebral Cortex - physiology
Clustering comparison
Connectome - methods
Grants
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Magnetic Resonance Imaging - methods
Methods
MRF
Parcellation
Pattern Recognition, Automated - methods
Resting-state fMRI
Sensitivity and Specificity
Software
Subtraction Technique
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Summary:Resting-state functional MRI is a powerful technique for mapping the functional organization of the human brain. However, for many types of connectivity analysis, high-resolution voxelwise analyses are computationally infeasible and dimensionality reduction is typically used to limit the number of network nodes. Most commonly, network nodes are defined using standard anatomic atlases that do not align well with functional neuroanatomy or regions of interest covering a small portion of the cortex. Data-driven parcellation methods seek to overcome such limitations, but existing approaches are highly dependent on initialization procedures and produce spatially fragmented parcels or overly isotropic parcels that are unlikely to be biologically grounded. In this paper, we propose a novel graph-based parcellation method that relies on a discrete Markov Random Field framework. The spatial connectedness of the parcels is explicitly enforced by shape priors. The shape of the parcels is adapted to underlying data through the use of functional geodesic distances. Our method is initialization-free and rapidly segments the cortex in a single optimization. The performance of the method was assessed using a large developmental cohort of more than 850 subjects. Compared to two prevalent parcellation methods, our approach provides superior reproducibility for a similar data fit. Furthermore, compared to other methods, it avoids incoherent parcels. Finally, the method's utility is demonstrated through its ability to detect strong brain developmental effects that are only weakly observed using other methods. •We present a novel graph-based method for the parcellation of rs-fMRI data.•A validation on a large neuro-developmental database (>850 scans) was done.•It suggests that our method is more reproducible than two alternate approaches.•The modularity of our model opens the way to multiple applications.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2014.11.008