Ex vivo 4D visualization of aortic valve dynamics in a murine model with optical coherence tomography

The heart and its mechanical components, especially the heart valves and leaflets, are under enormous strain and undergo fatigue, which impinge upon cardiac output. The knowledge about changes of the dynamic behavior and the possibility of early stage diagnosis could lead to the development of new t...

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Bibliographic Details
Published in:Biomedical optics express 2014-12, Vol.5 (12), p.4201-4212
Main Authors: Schnabel, Christian, Jannasch, Anett, Faak, Saskia, Waldow, Thomas, Koch, Edmund
Format: Article
Language:English
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Summary:The heart and its mechanical components, especially the heart valves and leaflets, are under enormous strain and undergo fatigue, which impinge upon cardiac output. The knowledge about changes of the dynamic behavior and the possibility of early stage diagnosis could lead to the development of new treatment strategies. Animal models are suited for the development and evaluation of new experimental approaches and therefor innovative imaging techniques are necessary. In this study, we present the time resolved visualization of healthy and calcified aortic valves in an ex vivo artificially stimulated heart model with 4D optical coherence tomography and high-speed video microscopy.
ISSN:2156-7085
2156-7085
DOI:10.1364/BOE.5.004201