Human megakaryocyte progenitors derived from hematopoietic stem cells of normal individuals are MHC class II-expressing professional APC that enhance Th17 and Th1/Th17 responses

Highlights • Human megakaryocyte progenitors (MKp) are MHC Class II expressing professional APC. • Human MKp express cytokines and mediators augmenting Th17 and Th1/Th17 response. • MKp augment Th17 response against Candida albicans , serious opportunistic pathogen. • Unlike MKp, mature MK and plate...

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Bibliographic Details
Published in:Immunology letters 2015-01, Vol.163 (1), p.84-95
Main Authors: Finkielsztein, Ariel, Schlinker, Alaina C, Zhang, Li, Miller, William M, Datta, Syamal K
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antigen-Presenting Cells - cytology
Antigen-Presenting Cells - immunology
Antigens, CD - immunology
Blood Platelets - cytology
Blood Platelets - immunology
Candida albicans
Cell Communication - immunology
Cytokines - immunology
Gene Expression Regulation
Histocompatibility Antigens Class II - immunology
Humans
Megakaryocyte Progenitor Cells - cytology
Megakaryocyte Progenitor Cells - immunology
Th1 Cells - cytology
Th1 Cells - immunology
Th17 Cells - cytology
Th17 Cells - immunology
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Summary:Highlights • Human megakaryocyte progenitors (MKp) are MHC Class II expressing professional APC. • Human MKp express cytokines and mediators augmenting Th17 and Th1/Th17 response. • MKp augment Th17 response against Candida albicans , serious opportunistic pathogen. • Unlike MKp, mature MK and platelets express only Class I and do not augment Th17. • MKp probably play immunologic role in conditions with extramedullary hematopoiesis.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2014.11.013