Postprandial triglycerides and adipose tissue storage of dietary fatty acids: Impact of menopause and estradiol

Objectives Postprandial lipemia worsens after menopause, but the mechanism remains unknown. The hypothesized menopause‐related postprandial lipemia would be (1) associated with reduced storage of dietary fatty acids (FA) as triglyceride (TG) in subcutaneous adipose tissue (SAT) and (2) improved by s...

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Published in:Obesity (Silver Spring, Md.) Md.), 2015-01, Vol.23 (1), p.145-153
Main Authors: Bessesen, Daniel H., Cox‐York, Kimberly A., Hernandez, Teri Lynn, Erickson, Christopher B., Wang, Hong, Jackman, Matt R., Pelt, Rachael E.
Format: Article
Language:English
Subjects:
Abdomen
Adult
Body fat
Cholesterol
Dietary Fats - metabolism
Estradiol - blood
Estradiol - pharmacology
Fatty acids
Fatty Acids - metabolism
Female
Humans
Lipid Metabolism - drug effects
Meals
Menopause
Menopause - metabolism
Middle Aged
Postprandial Period
Subcutaneous Fat - drug effects
Subcutaneous Fat - metabolism
Triglycerides - blood
Women
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Summary:Objectives Postprandial lipemia worsens after menopause, but the mechanism remains unknown. The hypothesized menopause‐related postprandial lipemia would be (1) associated with reduced storage of dietary fatty acids (FA) as triglyceride (TG) in subcutaneous adipose tissue (SAT) and (2) improved by short‐term estradiol (E2). Methods Twenty‐three pre‐ (mean ± SD: 42 ± 4 years) and 22 postmenopausal (55 ± 4 years) women with similar total adiposity were studied. A subset of postmenopausal women (n = 12) were studied following 2 weeks of E2 (0.15 mg) and matching placebo in a random, cross‐over design. A liquid meal containing 14C‐oleic acid traced appearance of dietary FA in: serum (postprandial TG), breath (oxidation), and abdominal and femoral SAT (TG storage). Results Compared to premenopausal women, healthy, lean, postmenopausal women had increased postprandial glucose and insulin and trend for higher TG but had similar dietary FA oxidation and storage. Adipocytes were larger in post‐ compared to premenopausal women, particularly in femoral SAT. Short‐term E2 reduced postprandial TG and insulin but had no effect on oxidation or storage of dietary FA. E2 increased the proportion of small adipocytes in femoral (but not abdominal) SAT. Conclusions Short‐term E2 attenuated menopause‐related increases in postprandial TG and increased femoral adipocyte hyperplasia but not through increased net storage of dietary FA.
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.20935