Association between vitamin D deficiency and mortality in critically ill adult patients: a meta-analysis of cohort studies

Vitamin D deficiency is common in critically ill patients, and was reported to be associated with adverse outcomes. However, the effect of vitamin D deficiency on mortality in critically ill patients remains unclear. We searched PubMed and EMBASE from the inception to July 2014 for cohort studies to...

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Published in:Critical care (London, England) England), 2014-12, Vol.18 (6), p.684-684, Article 684
Main Authors: Zhang, Yan-Peng, Wan, You-Dong, Sun, Tong-Wen, Kan, Quan-Cheng, Wang, Le-Xin
Format: Article
Language:English
Subjects:
Analysis
Cohort Studies
Complications and side effects
Critical Illness - mortality
Health aspects
Hospital Mortality - trends
Humans
Mortality
Patient outcomes
Vitamin D - blood
Vitamin D deficiency
Vitamin D Deficiency - blood
Vitamin D Deficiency - diagnosis
Vitamin D Deficiency - mortality
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Summary:Vitamin D deficiency is common in critically ill patients, and was reported to be associated with adverse outcomes. However, the effect of vitamin D deficiency on mortality in critically ill patients remains unclear. We searched PubMed and EMBASE from the inception to July 2014 for cohort studies to assess the effect of vitamin D deficiency on the incidence of mortality in critically ill patients. Mortality-specific odds ratio (OR) with 95% confidence interval (CI) were pooled with a random- or fixed-effect models when appropriate. Seven cohort studies with a total of 4,204 participants including 1,679 cases of vitamin D deficiency were included in this meta-analysis. Vitamin D deficiency was significantly associated with an increased hospital mortality (OR 1.76; 95% CI, 1.38 to 2.24; P < 0.001), with very low heterogeneity (I (2) = 2.3%; P = 0.402). The finding of increased hospital mortality in critically ill adult patients was consistently found in every stratum of our subgroup analyses. This meta-analysis suggests that vitamin D deficiency is associated with increased incidence of hospital mortality in critically ill adult patients.
ISSN:1364-8535
1466-609X
1364-8535
DOI:10.1186/s13054-014-0684-9