Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke

Background Evidence suggests the incidence of oral tongue squamous cell carcinoma is increasing in young patients, many who have no history of tobacco use. Methods We clinically reviewed 89 patients with oral tongue cancer. Exomic sequencing of tumor DNA from 6 nonsmokers was performed and compared...

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Bibliographic Details
Published in:Head & neck 2015-11, Vol.37 (11), p.1642-1649
Main Authors: Li, Ryan, Faden, Daniel L., Fakhry, Carole, Langelier, Chaz, Jiao, Yuchen, Wang, Yuxuan, Wilkerson, Matthew D., Pedamallu, Chandra Sekhar, Old, Matthew, Lang, James, Loyo, Myriam, Ahn, Sun Mi, Tan, Marietta, Gooi, Zhen, Chan, Jason, Richmon, Jeremy, Wood, Laura D., Hruban, Ralph H., Bishop, Justin, Westra, William H., Chung, Christine H., Califano, Joseph, Gourin, Christine G., Bettegowda, Chetan, Meyerson, Matthew, Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, DeRisi, Joseph L., Koch, Wayne M., Agrawal, Nishant
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Carcinoma, Squamous Cell - epidemiology
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - pathology
Cohort Studies
Databases, Factual
DNA, Neoplasm - genetics
Female
Genetic Predisposition to Disease - epidemiology
Genomics
head and neck cancer
Humans
Incidence
Male
Metagenome - genetics
Middle Aged
Mutation
Neoplasm Invasiveness - pathology
Neoplasm Staging
next-generation sequencing
nonsmokers
oral tongue
Prognosis
Retrospective Studies
Risk Assessment
RNA, Messenger - genetics
Sex Distribution
Smoking
squamous cell carcinoma
Tongue Neoplasms - epidemiology
Tongue Neoplasms - genetics
Tongue Neoplasms - pathology
Tumor Suppressor Protein p53 - genetics
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Summary:Background Evidence suggests the incidence of oral tongue squamous cell carcinoma is increasing in young patients, many who have no history of tobacco use. Methods We clinically reviewed 89 patients with oral tongue cancer. Exomic sequencing of tumor DNA from 6 nonsmokers was performed and compared to previously sequenced cases. RNA from 20 tumors was evaluated by massively parallel sequencing to search for potentially oncogenic viruses. Results Non‐smokers (53 of 89) were younger than smokers (36 of 89; mean, 50.4 vs 61.9 years; p 
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.23807