Single event-related changes in cerebral oxygenated hemoglobin using word game in schizophrenia

Neuroimaging studies have been conducted using word generation tasks and have shown greater hypofrontality in patients with schizophrenia compared with healthy subjects. In this study, we compared the characteristics of oxygenated hemoglobin changes involved in both phonological and categorical verb...

Full description

Saved in:
Bibliographic Details
Published in:Neuropsychiatric disease and treatment 2014-01, Vol.10, p.2353-2360
Main Authors: Fujiki, Ryo, Morita, Kiichiro, Sato, Mamoru, Yamashita, Yuji, Kato, Yusuke, Ishii, Yohei, Shoji, Yoshihisa, Uchimura, Naohisa
Format: Article
Language:English
Subjects:
biological marker
Bipolar disorder
Cerebral cortex
Disease
Evoked potentials (Electrophysiology)
Health aspects
Hemoglobin
hypofrontality
Males
Medical imaging
Memory
NMR
Nuclear magnetic resonance
Original Research
Physiological aspects
Psychiatry
Psychological aspects
Psychosis
Psychotropic drugs
Schizophrenia
single-event-related near-infrared spectroscopy
Spectrum analysis
Studies
Word games
word production task
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neuroimaging studies have been conducted using word generation tasks and have shown greater hypofrontality in patients with schizophrenia compared with healthy subjects. In this study, we compared the characteristics of oxygenated hemoglobin changes involved in both phonological and categorical verbal fluency between 35 outpatients with schizophrenia and 35 healthy subjects during a Japanese "shiritori" task using single-event-related near-infrared spectroscopy. During this task, the schizophrenic patients showed significantly smaller activation in the prefrontal cortex area than the controls. In addition, a significant positive correlation was obtained between oxygenated hemoglobin changes (prefrontal cortex area, inferior parietal area) and the severity of positive psychiatric symptoms. It is possible that hypofrontality of patients may be a diagnostic assistance tool for schizophrenia, and that the relationship between activation and positive syndrome scores may be of help in predicting functional outcome in patients.
ISSN:1176-6328
1178-2021
1178-2021
DOI:10.2147/NDT.S73975