Effect of low-dose dexketoprofen trometamol and paracetamol on postoperative complications after impacted third molar surgery on healthy volunteers: A pilot study

The aim of the present study was to investigate the analgesic and anti-inflammatory effects of dexketoprofen trometamol (DT) and paracetamol on deep acute somatic pain and inflammation in patients undergoing impacted third molar surgery. This study was planned to present benefits that we could obtai...

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Published in:Medicina oral, patología oral y cirugía bucal patología oral y cirugía bucal, 2014-11, Vol.19 (6), p.e622-e627
Main Authors: Eroglu, Cennet-Neslihan, Durmus, Ercan, Kiresi, Demet
Format: Article
Language:English
Subjects:
Acetaminophen - administration & dosage
Adolescent
Adult
Analgesics, Non-Narcotic - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Dentistry
Female
Humans
Inflammation - prevention & control
Ketoprofen - administration & dosage
Ketoprofen - analogs & derivatives
Male
Molar, Third - surgery
Pain, Postoperative - prevention & control
Pilot Projects
Postoperative Complications - prevention & control
Prospective Studies
Tooth, Impacted - surgery
Tromethamine - administration & dosage
Young Adult
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Summary:The aim of the present study was to investigate the analgesic and anti-inflammatory effects of dexketoprofen trometamol (DT) and paracetamol on deep acute somatic pain and inflammation in patients undergoing impacted third molar surgery. This study was planned to present benefits that we could obtain with low burden of drug. Effects of drugs, which were administered preemptively before the procedure, on pain, mouth-opening limitation, and swelling were assessed by visual analogue scale (VAS), magnetic resonance imaging (MRI), and mouth-opening measurement. Following surgery, time intervals when the patients first need to receive the drug were measured. The VAS scores of the patients were lower in the side treated with DT than that in the paracetamol treated side. There was no significant difference between the groups in terms of mouth-opening limitation. MRI recordings revealed that swelling was lower in the side treated with paracetamol than DT treated side. Administration of the drugs before surgery contributed to the postoperative patient comfort. The analgesic activity of 12.5 mg dose of DT was similar to, even better than, the analgesic activity of 500 mg dose of paracetamol; however, DT had insufficient anti-inflammatory efficacy.
ISSN:1698-6946
1698-4447
1698-6946
DOI:10.4317/medoral.19835