Shadow Enhancers as a Source of Evolutionary Novelty

Some developmentally important genes can be regulated via two enhancers, one located nearby and the other, a "shadow" enhancer, 10 to 20 kilobases away.

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2008-09, Vol.321 (5894), p.1314-1314
Main Authors: Hong, Joung-Woo, Hendrix, David A, Levine, Michael S
Format: Article
Language:English
Subjects:
Animals
Binding Sites
Biological and medical sciences
Biological evolution
Body Patterning - genetics
Brevia
Chromatin
Chromatin Immunoprecipitation
Computational Biology
Drosophila
Drosophila - embryology
Drosophila - genetics
Drosophila melanogaster - embryology
Drosophila melanogaster - genetics
Drosophila Proteins - metabolism
Ectoderm
Embryology: invertebrates and vertebrates. Teratology
Embryonic Development
Embryos
Enhancer Elements, Genetic
Evolution, Molecular
Evolutionary biology
Experimental organogenesis
Fundamental and applied biological sciences. Psychology
Gene expression
Gene Expression Regulation, Developmental
Genes
Genetics
Genetics of eukaryotes. Biological and molecular evolution
Genomics
Insects
Introns
Nuclear Proteins - metabolism
Oligonucleotide Array Sequence Analysis
Organogenesis. Physiological fonctions
Phosphoproteins - metabolism
Phylogeny
Stripes
Transcription Factors - metabolism
Transcription initiation site
Transgenic animals
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Description
Summary:Some developmentally important genes can be regulated via two enhancers, one located nearby and the other, a "shadow" enhancer, 10 to 20 kilobases away.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1160631