Mechanisms of heart failure in obesity

Summary Heart failure is a leading cause of morbidity and mortality and its prevalence continues to rise. Because obesity has been linked with heart failure, the increasing prevalence of obesity may presage further rise in heart failure in the future. Obesity-related factors are estimated to cause 1...

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Bibliographic Details
Published in:Obesity research & clinical practice 2014-11, Vol.8 (6), p.e540-e548
Main Authors: Ebong, Imo A, Goff, David C, Rodriguez, Carlos J, Chen, Haiying, Bertoni, Alain G
Format: Article
Language:English
Subjects:
Body Mass Index
Endocrinology & Metabolism
Female
Heart failure
Heart Failure - etiology
Heart Failure - physiopathology
Humans
Internal Medicine
Lipids - adverse effects
Male
Mechanisms
Obesity
Obesity - complications
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Summary:Summary Heart failure is a leading cause of morbidity and mortality and its prevalence continues to rise. Because obesity has been linked with heart failure, the increasing prevalence of obesity may presage further rise in heart failure in the future. Obesity-related factors are estimated to cause 11% of heart failure cases in men and 14% in women. Obesity may result in heart failure by inducing haemodynamic and myocardial changes that lead to cardiac dysfunction, or due to an increased predisposition to other heart failure risk factors. Direct cardiac lipotoxicity has been described where lipid accumulation in the heart results in cardiac dysfunction inexplicable of other heart failure risk factors. In this overview, we discussed various pathophysiological mechanisms that could lead to heart failure in obesity, including the molecular mechanisms underlying cardiac lipotoxicity. We defined the obesity paradox and enumerated various premises for the paradoxical associations observed in the relationship between obesity and heart failure.
ISSN:1871-403X
1878-0318
DOI:10.1016/j.orcp.2013.12.005