Brain-Derived Neurotrophic Factor in children with Autism Spectrum Disorder

Autism Spectrum Disorder (ASD) is a complex neurobehavioral syndrome with no known biomarker so far for early detection. It has been challenging, both to classify typical autism and associate a suitable biomarker with clinical phenotype spectrum. Brain-derived neurotrophic factor (BDNF) has emerged...

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Bibliographic Details
Published in:Annals of Neurosciences 2014-10, Vol.21 (4), p.129-133
Main Authors: Kasarpalkar, Nikhil J, Kothari, Sweta T, Dave, Usha P
Format: Article
Language:English
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Summary:Autism Spectrum Disorder (ASD) is a complex neurobehavioral syndrome with no known biomarker so far for early detection. It has been challenging, both to classify typical autism and associate a suitable biomarker with clinical phenotype spectrum. Brain-derived neurotrophic factor (BDNF) has emerged as a key neurotrophin regulating synaptic plasticity, neuronal differentiation and survival. Recently, BDNF depletion is reported in neurodegenerative as well as in psychiatric disorders, associated with severity of neurological dysfunction. Role of BDNF as a biomarker in ASD is gaining significance. Pre-clinical results have linked BDNF depletion in autism and mental retardation, however, with conflicting findings. In view of this, a preliminary study was carried out to measure serum BDNF levels in 48 children with ASD and mental retardation, and 29 age-matched controls. Serum BDNF levels were found significantly higher (p
ISSN:0972-7531
0976-3260
DOI:10.5214/ans.0972.7531.210403