Emerging markers of cachexia predict survival in cancer patients

Cachexia may occur in 40% of cancer patients, representing the major cause of death in more than 20% of them. The aim of this study was to investigate the role of leptin, ghrelin and obestatin as diagnostic and predictive markers of cachexia in oncologic patients. Their impact on patient survival wa...

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Bibliographic Details
Published in:BMC cancer 2014-11, Vol.14 (1), p.828, Article 828
Main Authors: Mondello, Patrizia, Lacquaniti, Antonio, Mondello, Stefania, Bolignano, Davide, Pitini, Vincenzo, Aloisi, Carmela, Buemi, Michele
Format: Article
Language:English
Subjects:
Aged
Area Under Curve
Biomarkers - blood
Blood diseases
Cachexia - blood
Cachexia - diagnosis
Cachexia - etiology
Cachexia - mortality
Case-Control Studies
Cholesterol - blood
Diabetes Mellitus - blood
Female
Follow-Up Studies
Ghrelin - blood
Heart Failure - blood
Humans
Kaplan-Meier Estimate
Leptin - blood
Male
Metabolic disorders
Middle Aged
Neoplasm Metastasis
Neoplasms - blood
Neoplasms - complications
Neoplasms - mortality
Peritoneal dialysis
Predictive Value of Tests
Proportional Hazards Models
ROC Curve
Rodents
Serum Albumin - metabolism
Survival Rate
Weight control
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Summary:Cachexia may occur in 40% of cancer patients, representing the major cause of death in more than 20% of them. The aim of this study was to investigate the role of leptin, ghrelin and obestatin as diagnostic and predictive markers of cachexia in oncologic patients. Their impact on patient survival was also evaluated. 140 adults with different cancer diagnoses were recruited. Thirty healthy volunteers served as control. Serum ghrelin, obestatin and leptin were tested at baseline and after a follow-up period of 18 months. Ghrelin levels were significantly higher in cancer patients than in healthy subjects (573.31 ± 130 vs 320.20 ± 66.48 ng/ml, p 
ISSN:1471-2407
1471-2407
DOI:10.1186/1471-2407-14-828