Oxidants, antioxidants and mitochondrial function in non-proliferative diabetic retinopathy (在非增殖性糖尿病视网膜病变中的氧化剂、抗氧化剂以及线粒体功能)

Background Diabetic retinopathy (DR) is a preventable cause of visual disability. The aims of the present study were to investigate levels and behavior oxidative stress markers and mitochondrial function in non‐proliferative DR (NPDR) and to establish the correlation between the severity of NPDR and...

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Published in:Journal of diabetes 2014-03, Vol.6 (2), p.167-175
Main Authors: Rodríguez-Carrizalez, Adolfo Daniel, Castellanos-González, José Alberto, Martínez-Romero, Esaú César, Miller-Arrevillaga, Guillermo, Villa-Hernández, David, Hernández-Godínez, Pedro Pablo, Ortiz, Genaro Gabriel, Pacheco-Moisés, Fermín Paul, Cardona-Muñoz, Ernesto Germán, Miranda-Díaz, Alejandra Guillermina
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Adult
Aged
Antioxidants - metabolism
Catalase - metabolism
diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - metabolism
diabetic retinopathy
Diabetic Retinopathy - blood
Diabetic Retinopathy - etiology
Diabetic Retinopathy - metabolism
Erythrocytes - metabolism
Female
Glutathione Peroxidase - metabolism
Humans
Hydrolysis
Lipid Peroxidation
Male
Membrane Fluidity
Middle Aged
Mitochondria - metabolism
Mitochondria - physiology
Mitochondrial Membranes - chemistry
Mitochondrial Membranes - metabolism
Multivariate Analysis
Nitric Oxide - metabolism
nitrosative stress
Original
Oxidants - metabolism
oxidative stress
Proton-Translocating ATPases - metabolism
糖尿病，糖尿病视网膜病变，膜流动性，硝化应激，氧化应激
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Summary:Background Diabetic retinopathy (DR) is a preventable cause of visual disability. The aims of the present study were to investigate levels and behavior oxidative stress markers and mitochondrial function in non‐proliferative DR (NPDR) and to establish the correlation between the severity of NPDR and markers of oxidative stress and mitochondrial function. Methods In a transverse analysis, type 2 diabetes mellitus (T2DM) patients with mild, moderate and severe non‐proliferative DR (NPDR) were evaluated for markers of oxidative stress (i.e. products of lipid peroxidation (LPO) and nitric oxide (NO) catabolites) and antioxidant activity (i.e. total antioxidant capacity (TAC), catalase, and glutathione peroxidase (GPx) activity of erythrocytes). Mitochondrial function was also determined as the fluidity of the submitochondrial particles of platelets and the hydrolytic activity of F0/F1‐ATPase. Results Levels of LPO and NO were significantly increased in T2DM patients with severe NPDR (3.19 ± 0.05 μmol/mL and 45.62 ± 1.27 pmol/mL, respectively; P 
ISSN:1753-0393
1753-0407
DOI:10.1111/1753-0407.12076