Analysis of image formation in optical coherence elastography using a multiphysics approach

IMAGE FORMATION IN OPTICAL COHERENCE ELASTOGRAPHY (OCE) RESULTS FROM A COMBINATION OF TWO PROCESSES: the mechanical deformation imparted to the sample and the detection of the resulting displacement using optical coherence tomography (OCT). We present a multiphysics model of these processes, validat...

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Bibliographic Details
Published in:Biomedical optics express 2014-09, Vol.5 (9), p.2913-2930
Main Authors: Chin, Lixin, Curatolo, Andrea, Kennedy, Brendan F, Doyle, Barry J, Munro, Peter R T, McLaughlin, Robert A, Sampson, David D
Format: Article
Language:English
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Summary:IMAGE FORMATION IN OPTICAL COHERENCE ELASTOGRAPHY (OCE) RESULTS FROM A COMBINATION OF TWO PROCESSES: the mechanical deformation imparted to the sample and the detection of the resulting displacement using optical coherence tomography (OCT). We present a multiphysics model of these processes, validated by simulating strain elastograms acquired using phase-sensitive compression OCE, and demonstrating close correspondence with experimental results. Using the model, we present evidence that the approximation commonly used to infer sample displacement in phase-sensitive OCE is invalidated for smaller deformations than has been previously considered, significantly affecting the measurement precision, as quantified by the displacement sensitivity and the elastogram signal-to-noise ratio. We show how the precision of OCE is affected not only by OCT shot-noise, as is usually considered, but additionally by phase decorrelation due to the sample deformation. This multiphysics model provides a general framework that could be used to compare and contrast different OCE techniques.
ISSN:2156-7085
2156-7085
DOI:10.1364/boe.5.002913