Serum uric acid levels are associated with polymorphisms in the SLC2A9, SF1, and GCKR genes in a Chinese population

Aim： Genome-wide association studies have identified several novel loci associated with serum uric acid concentrations in individuals of European descent. In the current study, we aimed to evaluate the associations between these loci and serum uric acid concentrations in a Chinese population. Method...

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Published in:Acta pharmacologica Sinica 2014-11, Vol.35 (11), p.1421-1427
Main Authors: Sun, Xue, Jiang, Feng, Zhang, Rong, Tang, Shan-shan, Chen, Miao, Peng, Dan-feng, Yan, Jing, Wang, Tao, Wang, Shi-yun, Bao, Yu-qian, Hu, Cheng, Jia, Wei-ping
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - genetics
Adaptor Proteins, Signal Transducing - metabolism
Adult
Aged
Asian Continental Ancestry Group - genetics
China
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Female
Gene Frequency
Genome-Wide Association Study
Genotype
Glucose Transport Proteins, Facilitative - genetics
Glucose Transport Proteins, Facilitative - metabolism
Humans
KR基因
Male
Middle Aged
Original
Phenotype
Polymorphism, Single Nucleotide
RNA Splicing Factors
Sex Factors
Transcription Factors - genetics
Transcription Factors - metabolism
Uric Acid - blood
中国人群
单核苷酸多态性
基因多态性
血尿
血清生化指标
酸水
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Summary:Aim： Genome-wide association studies have identified several novel loci associated with serum uric acid concentrations in individuals of European descent. In the current study, we aimed to evaluate the associations between these loci and serum uric acid concentrations in a Chinese population. Methods： Fourteen single nucleotide polymorphisms （SNPs） mapped in or near 11 loci （PDZK1, GCKR, LRP2, SLC2A9, ABCG2, LRRC16A, SLC17A1, SLC17A3, SLC22A11, SLC22A12 and SF1） were genotyped in 2329 Chinese subjects in Shanghai. Serum biochemical parameters including uric acid concentrations were determined. All the variants were analyzed for gender differences since uric acid metabolism differed between genders. Results： In males after adjustments for age and BMI, GCKR rs780094, SLC2A9 rs11722228 and SF1 rs606458 were associated with the uric acid concentrations, which were statistically significant （P=0.016, 0.001 and 0.03, respectively）, whereas SLC2A9 rs3775948 was marginally associated with the uric acid concentrations （P=O.071）. In females, SLC22A12 rs506338 was also marginally associated with the uric acid concentrations （P--0.057）. The meta-analysis for combined data from both males and females revealed that rs3775948 and rs606458 were associated with the uric acid concentrations （P=0.036 and 0.043, respectively）. Furthermore, the gender significantly affected the association of rs11722228 with serum uric acid levels （P=0.012）. Conclusion： The SLC2A9 rs11722228, SF1 rs606458 and GCKR rs780094 variants modulate uric acid concentrations in Chinese males, while SF1 rs606458 and SLC2A9 rs3775948 are associated with the uric acid concentrations in both Chinese males and females.
ISSN:1671-4083
1745-7254
DOI:10.1038/aps.2014.87