Reproducibility and accuracy of optic nerve sheath diameter assessment using ultrasound compared to magnetic resonance imaging

Quantification of the optic nerve sheath diameter (ONSD) by transbulbar sonography is a promising non-invasive technique for the detection of altered intracranial pressure. In order to establish this method as follow-up tool in diseases with intracranial hyper- or hypotension scan-rescan reproducibi...

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Bibliographic Details
Published in:BMC neurology 2013-12, Vol.13 (1), p.187-187, Article 187
Main Authors: Bäuerle, Jochen, Schuchardt, Florian, Schroeder, Laure, Egger, Karl, Weigel, Matthias, Harloff, Andreas
Format: Article
Language:English
Subjects:
Accuracy
Acquisitions & mergers
Adult
Age
Health aspects
Healthy Volunteers
Humans
Magnetic Resonance Imaging
Myelin Sheath - diagnostic imaging
NMR
Nuclear magnetic resonance
Observer Variation
Optic nerve
Optic Nerve - anatomy & histology
Optic Nerve - diagnostic imaging
Reproducibility of Results
Retrospective Studies
Studies
Ultrasonic imaging
Ultrasonography, Doppler, Transcranial
Ultrasound imaging
Volunteers
Young Adult
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Summary:Quantification of the optic nerve sheath diameter (ONSD) by transbulbar sonography is a promising non-invasive technique for the detection of altered intracranial pressure. In order to establish this method as follow-up tool in diseases with intracranial hyper- or hypotension scan-rescan reproducibility and accuracy need to be systematically investigated. The right ONSD of 15 healthy volunteers (mean age 24.5 ± 0.8 years) were measured by both transbulbar sonography (9 - 3 MHz) and 3 Tesla MRI (half-Fourier acquisition single-shot turbo spin-echo sequences, HASTE) 3 and 5 mm behind papilla. All volunteers underwent repeated ultrasound and MRI examinations in order to assess scan-rescan reproducibility and accuracy. Moreover, inter- and intra-observer variabilities were calculated for both techniques. Scan-rescan reproducibility was robust for ONSD quantification by sonography and MRI at both depths (r > 0.75, p ≤ 0.001, mean differences < 2%). Comparing ultrasound- and MRI-derived ONSD values, we found acceptable agreement between both methods for measurements at a depth of 3 mm (r = 0.72, p = 0.002, mean difference < 5%). Further analyses revealed good inter- and intra-observer reliability for sonographic measurements 3 mm behind the papilla and for MRI at 3 and 5 mm (r > 0.82, p < 0.001, mean differences < 5%). Sonographic ONSD quantification 3 mm behind the papilla can be performed with good reproducibility, measurement accuracy and observer agreement. Thus, our findings emphasize the feasibility of this technique as a non-invasive bedside tool for longitudinal ONSD measurements.
ISSN:1471-2377
1471-2377
DOI:10.1186/1471-2377-13-187