GluA1 promotes the activity-dependent development of motor circuitry in the developing segmental spinal cord

The neuronal dendritic tree is a key determinant of how neurons receive, compute, and transmit information. During early postnatal life, synaptic activity promotes dendrite elaboration. Spinal motor neurons utilize GluA1‐containing AMPA (2‐amino‐3‐(3‐hydroxy‐5‐methyl‐isoxazol‐4‐yl) propanoic acid) r...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2013-03, Vol.1279 (1), p.54-59
Main Authors: Jablonski, Angela M., Kalb, Robert G.
Format: Article
Language:English
Subjects:
activity dependent
AMPA
Animals
dendrite
development
GluA1
growth
Humans
Models, Biological
Motor Neurons - metabolism
Motor Neurons - physiology
Nerve Net - embryology
Nerve Net - growth & development
Nerve Net - metabolism
Neurogenesis - genetics
Neurogenesis - physiology
Neurons
Receptors, AMPA - genetics
Receptors, AMPA - metabolism
Receptors, AMPA - physiology
Spinal Cord - cytology
Spinal Cord - embryology
Spinal Cord - growth & development
Spinal Cord - metabolism
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Summary:The neuronal dendritic tree is a key determinant of how neurons receive, compute, and transmit information. During early postnatal life, synaptic activity promotes dendrite elaboration. Spinal motor neurons utilize GluA1‐containing AMPA (2‐amino‐3‐(3‐hydroxy‐5‐methyl‐isoxazol‐4‐yl) propanoic acid) receptors (AMPA‐R) to control this process. This form of developmental dendrite growth can occur independently of N‐methyl‐d‐aspartate receptors (NMDA‐R). This review focuses on the mechanism by which the GluA1 subunit of AMPA‐R transforms synaptic activity into dendrite growth, and describes the essential role of the GluA1 binding partner SAP97 (synapse‐associated protein of 97 kDa molecular weight) in this process. This work defines a new mechanism of activity‐dependent development, which might be harnessed to stimulate the recovery of function following insult to the central nervous system.
ISSN:0077-8923
1749-6632
DOI:10.1111/nyas.12053