Age-related increases in right frontal activation during task switching are mediated by reaction time and white matter microstructure

Highlights • Age-related activation increases in the right dorsolateral PFC (DLPFC) and insula. • Older adult group showed longer RT and decreased WM integrity in the corpus callosum. • Age-related increases in right insula activation were mediated by RT slowing. • Age-related increases in right DLP...

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Bibliographic Details
Published in:Neuroscience 2014-10, Vol.278, p.51-61
Main Authors: Zhu, Z, Hakun, J.G, Johnson, N.F, Gold, B.T
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
aging
Brain Mapping
Cognition - physiology
Diffusion Tensor Imaging
DTI
Female
Frontal Lobe - cytology
Frontal Lobe - physiology
Functional Laterality
Humans
Magnetic Resonance Imaging
Male
mediation
Middle Aged
neural efficiency
Neurology
over-recruitment
Reaction Time - physiology
task switching
White Matter - cytology
White Matter - physiology
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Summary:Highlights • Age-related activation increases in the right dorsolateral PFC (DLPFC) and insula. • Older adult group showed longer RT and decreased WM integrity in the corpus callosum. • Age-related increases in right insula activation were mediated by RT slowing. • Age-related increases in right DLPFC activation were mediated by WM integrity declines.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.07.076