Nanoparticles prepared from porous silicon nanowires for bio-imaging and sonodynamic therapy

Evaluation of cytotoxicity, photoluminescence, bio-imaging, and sonosensitizing properties of silicon nanoparticles (SiNPs) prepared by ultrasound grinding of porous silicon nanowires (SiNWs) have been investigated. SiNWs were formed by metal (silver)-assisted wet chemical etching of heavily boron-d...

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Bibliographic Details
Published in:Nanoscale research letters 2014-09, Vol.9 (1), p.463-463, Article 463
Main Authors: Osminkina, Liubov A, Sivakov, Vladimir A, Mysov, Grigory A, Georgobiani, Veronika A, Natashina, Ulyana А, Talkenberg, Florian, Solovyev, Valery V, Kudryavtsev, Andrew A, Timoshenko, Victor Yu
Format: Article
Language:English
Subjects:
Chemistry and Materials Science
Materials Science
Molecular Medicine
Nano Express
Nanochemistry
Nanoscale Science and Technology
Nanotechnology
Nanotechnology and Microengineering
Porous Semiconductors - Science and Technology PSST2014
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Summary:Evaluation of cytotoxicity, photoluminescence, bio-imaging, and sonosensitizing properties of silicon nanoparticles (SiNPs) prepared by ultrasound grinding of porous silicon nanowires (SiNWs) have been investigated. SiNWs were formed by metal (silver)-assisted wet chemical etching of heavily boron-doped (100)-oriented single crystalline silicon wafers. The prepared SiNWs and aqueous suspensions of SiNPs exhibit efficient room temperature photoluminescence (PL) in the spectral region of 600 to 1,000 nm that is explained by the radiative recombination of excitons confined in small silicon nanocrystals, from which SiNWs and SiNPs consist of. On the one hand, in vitro studies have demonstrated low cytotoxicity of SiNPs and possibilities of their bio-imaging applications. On the other hand, it has been found that SiNPs can act as efficient sensitizers of ultrasound-induced suppression of the viability of Hep-2 cancer cells.
ISSN:1931-7573
1556-276X
1556-276X
DOI:10.1186/1556-276X-9-463