Associations between arsenic species in exfoliated urothelial cells and prevalence of diabetes among residents of Chihuahua, Mexico

A growing number of studies link chronic exposure to inorganic arsenic (iAs) with the risk of diabetes. Many of these studies assessed iAs exposure by measuring arsenic (As) species in urine. However, this approach has been criticized because of uncertainties associated with renal function and urine...

Full description

Saved in:
Bibliographic Details
Published in:Environmental health perspectives 2014-10, Vol.122 (10), p.1088-1094
Main Authors: Currier, Jenna M, Ishida, María C, González-Horta, Carmen, Sánchez-Ramírez, Blanca, Ballinas-Casarrubias, Lourdes, Gutiérrez-Torres, Daniela S, Cerón, Roberto Hernández, Morales, Damián Viniegra, Terrazas, Francisco A Baeza, Del Razo, Luz M, García-Vargas, Gonzalo G, Saunders, R Jesse, Drobná, Zuzana, Fry, Rebecca C, Matoušek, Tomáš, Buse, John B, Mendez, Michelle A, Loomis, Dana, Stýblo, Miroslav
Format: Article
Language:English
Subjects:
Adult
Antidiabetics
Arsenic
Arsenic - analysis
Arsenic - metabolism
Arsenic - urine
Arsenic Poisoning
Arsenicals - analysis
Arsenicals - metabolism
Arsenicals - urine
Biomarkers - metabolism
Blood Glucose - analysis
Body mass index
Chronic illnesses
Creatinine
Diabetes
Diabetes Mellitus - chemically induced
Diabetes Mellitus - epidemiology
Drinking water
Environmental aspects
Environmental Exposure - adverse effects
Environmental Exposure - statistics & numerical data
Epithelial Cells - chemistry
Epithelial Cells - metabolism
Exfoliation
Exposure
Fasting
Female
Glucose
Glucose Tolerance Test
Health
Health aspects
Health risks
Humans
Leukocytes
Male
Metabolism
Metabolites
Mexico - epidemiology
Middle Aged
Oxidation
Plasma
Prevalence
Ratios
Renal function
Risk factors
Scientific imaging
Studies
Uncertainty
Urine
Urothelium - chemistry
Urothelium - metabolism
Water Pollutants, Chemical - analysis
Water Pollutants, Chemical - metabolism
Water Pollutants, Chemical - urine
Water Supply - analysis
Water Supply - statistics & numerical data
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A growing number of studies link chronic exposure to inorganic arsenic (iAs) with the risk of diabetes. Many of these studies assessed iAs exposure by measuring arsenic (As) species in urine. However, this approach has been criticized because of uncertainties associated with renal function and urine dilution in diabetic individuals. Our goal was to examine associations between the prevalence of diabetes and concentrations of As species in exfoliated urothelial cells (EUC) as an alternative to the measures of As in urine. We measured concentrations of trivalent and pentavalent iAs methyl-As (MAs) and dimethyl-As (DMAs) species in EUC from 374 residents of Chihuahua, Mexico, who were exposed to iAs in drinking water. We used fasting plasma glucose, glucose tolerance tests, and self-reported diabetes diagnoses or medication to identify diabetic participants. Associations between As species in EUC and diabetes were estimated using logistic and linear regression, adjusting for age, sex, and body mass index. Interquartile-range increases in trivalent, but not pentavalent, As species in EUC were positively and significantly associated with diabetes, with ORs of 1.57 (95% CI: 1.19, 2.07) for iAsIII, 1.63 (1.24, 2.15) for MAsIII, and 1.31 (0.96, 1.84) for DMAsIII. DMAs/MAs and DMAs/iAs ratios were negatively associated with diabetes (OR = 0.62; 95% CI: 0.47, 0.83 and OR = 0.72; 95% CI: 0.55, 0.96, respectively). Our data suggest that uncertainties associated with measures of As species in urine may be avoided by using As species in EUC as markers of iAs exposure and metabolism. Our results provide additional support to previous findings suggesting that trivalent As species may be responsible for associations between diabetes and chronic iAs exposure.
ISSN:0091-6765
1552-9924
DOI:10.1289/ehp.1307756