Levofloxacin for the treatment of severe refractory BK virus-associated hemorrhagic cystitis in hematopoietic stem cell transplantation recipients: A report of three cases

BK-virus (BKV) is an important etiological agent for late-onset hemorrhagic cystitis (HC) in patients undergoing hematopoietic stem cell transplantation. Late-onset HC causes significant morbidity among these patients. Therapeutic approaches remain predominantly symptomatic. Several treatment option...

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Bibliographic Details
Published in:Oncology letters 2014-10, Vol.8 (4), p.1775-1777
Main Authors: TOPTAS, TAYFUR, KAYGUSUZ-ATAGUNDUZ, ISIK, KANI, HALUK TARIK, ADIGUZEL, CAFER, FIRATLI-TUGLULAR, TULIN
Format: Article
Language:English
Subjects:
Adenoviruses
Antibiotics
Bacterial infections
BK virus
Blood clots
Chemotherapy
Cytomegalovirus
hematopoietic stem cell transplantation
hemorrhagic cystitis
Infections
Leukemia
levofloxacin
Morbidity
Patients
Stem cell transplantation
Stem cells
Studies
Transplants & implants
Urine
Viral infections
Viruses
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Summary:BK-virus (BKV) is an important etiological agent for late-onset hemorrhagic cystitis (HC) in patients undergoing hematopoietic stem cell transplantation. Late-onset HC causes significant morbidity among these patients. Therapeutic approaches remain predominantly symptomatic. Several treatment options have been used with variable success rates. Cidofovir has the highest specificity against BKV; however, its lack of availability in the majority of countries, high costs and potential nephrotoxic effects limit its use. The present study reports three cases of severe and prolonged BKV-associated HC (BKHC). HC was resolved in all three of the patients using oral levofloxacin. Thus, levofloxacin may be an effective treatment modality for achieving complete clinical and molecular response in patients with refractory, severe BKHC.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2014.2381