Gastrointestinal symptoms: A comparison between patients undergoing peritoneal dialysis and hemodialysis

AIM: To compare the prevalence and diversity of gastrointestinal(GI) symptoms in patients undergoing peritoneal dialysis(PD) and hemodialysis(HD).METHODS: Two hundred and ninety-four end-stage renal disease patients participated in the study, including 182 HD and 112 PD patients. Dimension scores we...

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Published in:World journal of gastroenterology : WJG 2014-08, Vol.20 (32), p.11370-11375
Main Authors: Dong, Rui, Guo, Zhi-Yong, Ding, Jia-Rong, Zhou, Yang-Yang, Wu, Hao
Format: Article
Language:English
Subjects:
Adult
Aged
Chi-Square Distribution
China - epidemiology
Female
Gastrointestinal
Gastrointestinal Diseases - diagnosis
Gastrointestinal Diseases - epidemiology
Hemodialysis
Humans
Kidney Failure, Chronic - diagnosis
Kidney Failure, Chronic - epidemiology
Kidney Failure, Chronic - therapy
Male
Middle Aged
Peritoneal
Peritoneal Dialysis - adverse effects
Prevalence
Renal Dialysis - adverse effects
Retrospective Studies
Retrospective Study
Risk Factors
Severity of Illness Index
Surveys and Questionnaires
symptom
Treatment Outcome
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Summary:AIM: To compare the prevalence and diversity of gastrointestinal(GI) symptoms in patients undergoing peritoneal dialysis(PD) and hemodialysis(HD).METHODS: Two hundred and ninety-four end-stage renal disease patients participated in the study, including 182 HD and 112 PD patients. Dimension scores were calculated from a modified gastrointestinal symptom rating scale(GSRS) 18-item questionnaire, including items concerning eating dysfunction, and were used for measuring GI symptoms. Information on patient age, condition contributing to end-stage renal disease and the most recent dialysis adequacy assessment(serum Kt/V urea value) was obtained from the follow-up database and by interviewing patients and/or reviewing the medical records. Differences between the HD and PD groups were evaluated using Student’s t, Pearson’s χ2 or Fisher’s exact tests.RESULTS: The overall prevalence of GI symptoms,defined by a GSRS > 1, in end-stage renal disease patients was 70.7%(208/294), which differed between HD and PD patients(76.4% vs 61.6%, P < 0.01). HD patients had a higher prevalence of constipation, abdominal pain and diarrhea compared to PD patients(36.3% vs 17.9%, 32.4% vs 5.4%, 17.6% vs 4.5%, respectively, P < 0.05). PD patients had a higher prevalence of reflux compared to HD patients(32.1% vs 24.2%, P < 0.05). Additionally, reflux and eating dysfunction were more severe in PD patients(GSRS: 1.71 ± 1.15 vs 1.30 ± 0.67, 1.57 ± 0.84 vs 1.39 ± 0.61, respectively, P < 0.05), whereas HD patients had greater abdominal pain, diarrhea and constipation(GSRS: 1.22 ± 0.39 vs 1.04 ± 0.19, 1.19 ± 0.53 vs 1.07 ± 0.35, 1.51 ± 0.83 vs 1.23 ± 0.58, respectively, P < 0.05). Finally, 14.8%(27/182) of HD patients presented with more than three GI symptoms, compared to 7.2%(8/112) of PD patients(P < 0.01).CONCLUSION: HD and PD patients differ in prevalence, severity and diversity of GI symptoms.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v20.i32.11370