A smart and versatile theranostic nanomedicine platform based on nanoporphyrin

Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. However, attaining consistently high performance of these functions in vivo in one single nanoconstruct remains extremely challenging. Here we demonstrate the use of...

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Bibliographic Details
Published in:	Nature communications 2014-08, Vol.5 (1), p.4712-4712, Article 4712
Main Authors:	Li, Yuanpei, Lin, Tzu-Yin, Luo, Yan, Liu, Qiangqiang, Xiao, Wenwu, Guo, Wenchang, Lac, Diana, Zhang, Hongyong, Feng, Caihong, Wachsmann-Hogiu, Sebastian, Walton, Jeffrey H, Cherry, Simon R, Rowland, Douglas J, Kukis, David, Pan, Chongxian, Lam, Kit S
Format:	Article
Language:	eng
Subjects:	Animals Cell Line, Tumor - drug effects Dendrimers - chemistry Doxorubicin - administration & dosage Doxorubicin - chemistry Drug Carriers - chemistry Drug Carriers - pharmacokinetics Female Fluorescence Humans Magnetic Resonance Imaging - methods Male Mice, Nude Mice, Transgenic Nanostructures - administration & dosage Nanostructures - chemistry Nanostructures - therapeutic use Photochemotherapy - methods Porphyrins - blood Porphyrins - chemistry Porphyrins - pharmacokinetics Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Spectroscopy, Near-Infrared - methods Theranostic Nanomedicine - instrumentation Theranostic Nanomedicine - methods
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Summary:	Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. However, attaining consistently high performance of these functions in vivo in one single nanoconstruct remains extremely challenging. Here we demonstrate the use of one single polymer to develop a smart 'all-in-one' nanoporphyrin platform that conveniently integrates a broad range of clinically relevant functions. Nanoporphyrins can be used as amplifiable multimodality nanoprobes for near-infrared fluorescence imaging (NIRFI), magnetic resonance imaging (MRI), positron emission tomography (PET) and dual modal PET-MRI. Nanoporphyrins greatly increase the imaging sensitivity for tumour detection through background suppression in blood, as well as preferential accumulation and signal amplification in tumours. Nanoporphyrins also function as multiphase nanotransducers that can efficiently convert light to heat inside tumours for photothermal therapy (PTT), and light to singlet oxygen for photodynamic therapy (PDT). Furthermore, nanoporphyrins act as programmable releasing nanocarriers for targeted delivery of drugs or therapeutic radio-metals into tumours.
ISSN:	2041-1723 2041-1723