Potential role of NADPH oxidase in pathogenesis of pancreatitis

Studies have demonstrated that reactive oxygen species(ROS) are closely related to inflammatory disorders. Nicotinamide adenine dinucleotide phosphate oxidase(NOX), originally found in phagocytes, is the main source of ROS in nonphagocytic cells. Besides directly producing the detrimental highly rea...

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Bibliographic Details
Published in:World journal of gastrointestinal pathophysiology 2014-08, Vol.5 (3), p.169-177
Main Authors: Cao, Wei-Li, Xiang, Xiao-Hui, Chen, Kai, Xu, Wei, Xia, Shi-Hai
Format: Article
Language:English
Subjects:
acinar
adenine
cells
dinucleotide
Nicotinamide
oxidase
oxygen
Pancreatic
Pancreatitis
phosphate
Reactive
species
stellate
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Summary:Studies have demonstrated that reactive oxygen species(ROS) are closely related to inflammatory disorders. Nicotinamide adenine dinucleotide phosphate oxidase(NOX), originally found in phagocytes, is the main source of ROS in nonphagocytic cells. Besides directly producing the detrimental highly reactive ROS to act on biomolecules(lipids, proteins, and nucleic acids), NOX can also activate multiple signal transduction pathways, which regulate cell growth, proliferation, differentiation and apoptosis by producing ROS. Recently, research on pancreatic NOX is no longer limited to inflammatory cells, but extends to the aspect of pancreatic acinar cells and pancreatic stellate cells, which are considered to be potentially associated with pancreatitis. In this review, we summarize the literature on NOX protein structure, activation, function and its role in the pathogenesis of pancreatitis.
ISSN:2150-5330
2150-5330
DOI:10.4291/wjgp.v5.i3.169