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Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice
AIM： To study isolation and chemical characterization of pectin derived from the common cranberry Vaccin/um oxycoccos L. （oxycoccusan OP） and the testing of its preventive effect on experimental colitis. METHODS： Mice were administrated orally with OP two days prior to a rectal injection of 5% aceti...
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| Published in: | World journal of gastroenterology : WJG 2006-11, Vol.12 (41), p.6646-6651 |
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| creator | Popov, Sergey V Markov, Pavel A Nikitina, Ida-R Petrishev, Sergey Smirnov, Vasily Ovodov, Yury S |
| description | AIM： To study isolation and chemical characterization of pectin derived from the common cranberry Vaccin/um oxycoccos L. （oxycoccusan OP） and the testing of its preventive effect on experimental colitis. METHODS： Mice were administrated orally with OP two days prior to a rectal injection of 5% acetic acid and examined for colonic damage 24 h later. Colonic inflammation was characterized by macroscopical injury and enhanced levels of myeloperoxidase activity measured spectrophotometrically with o-phenylene diamine as the substrate. The mucus contents of the colon were determined by the Alcian blue dye binding method. Vascular permeability was estimated using 4% Evans blue passage after i.p. injection of 0.05 mol/L acetic acid. RESULTS： In the mice treated with OP, colonic macroscopic scores （1.1 ± 0.4 vs 2.7, P 〈 0.01） and the total square area of damage （10 ± 2 vs 21 ± 7, P 〈 0.01） were significantly reduced when compared with the vehicle-treated colitis group. OP was shown to decrease the tissue myeloperoxidase activity in colons （42 ± 11 vs 112 ± 40, P 〈 0.01） and enhance the amount of mucus of colitis mice （0.9 ± 0.1 vs 0.4 ± 0.1, P 〈 0.01）. The level of colonic malondialdehyde was noted to decrease in OP-pretreated mice （3.6 ± 0.7 vs 5.1 ± 0.8, P 〈 0.01）. OP was found to decrease the inflammatory status of mice as was determined by reduction of vascular permeability （161 ± 34 vs 241 ± 21, P 〈 0.01）. Adhesion of peritoneal neutrophils and macrophages was also shown to decrease after administration of OP （141 ± 50 vs 235 ± 37, P 〈 0.05）. CONCLUSION： Thus, a preventive effect of pectin from the common cranberry, namely oxycoccusan OP, on acetic acid-induced colitis in mice was detected. A reduction of neutrophil infiltration and antioxidant action may be implicated in the protective effect of oxycoccusan. |
| doi_str_mv | 10.3748/wjg.v12.i41.6646 |
| format | article |
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METHODS： Mice were administrated orally with OP two days prior to a rectal injection of 5% acetic acid and examined for colonic damage 24 h later. Colonic inflammation was characterized by macroscopical injury and enhanced levels of myeloperoxidase activity measured spectrophotometrically with o-phenylene diamine as the substrate. The mucus contents of the colon were determined by the Alcian blue dye binding method. Vascular permeability was estimated using 4% Evans blue passage after i.p. injection of 0.05 mol/L acetic acid. RESULTS： In the mice treated with OP, colonic macroscopic scores （1.1 ± 0.4 vs 2.7, P 〈 0.01） and the total square area of damage （10 ± 2 vs 21 ± 7, P 〈 0.01） were significantly reduced when compared with the vehicle-treated colitis group. OP was shown to decrease the tissue myeloperoxidase activity in colons （42 ± 11 vs 112 ± 40, P 〈 0.01） and enhance the amount of mucus of colitis mice （0.9 ± 0.1 vs 0.4 ± 0.1, P 〈 0.01）. The level of colonic malondialdehyde was noted to decrease in OP-pretreated mice （3.6 ± 0.7 vs 5.1 ± 0.8, P 〈 0.01）. OP was found to decrease the inflammatory status of mice as was determined by reduction of vascular permeability （161 ± 34 vs 241 ± 21, P 〈 0.01）. Adhesion of peritoneal neutrophils and macrophages was also shown to decrease after administration of OP （141 ± 50 vs 235 ± 37, P 〈 0.05）. CONCLUSION： Thus, a preventive effect of pectin from the common cranberry, namely oxycoccusan OP, on acetic acid-induced colitis in mice was detected. A reduction of neutrophil infiltration and antioxidant action may be implicated in the protective effect of oxycoccusan.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v12.i41.6646</identifier><identifier>PMID: 17075978</identifier><language>eng</language><publisher>United States: Department of Molecular Immunology and Biotechnology, Institute of Physiology, Komi Science Centre, The Urals Branch of the Russian Academy of Sciences, 50 Pervomaiskaya str., Syktyvkar 167982, Russia</publisher><subject>Acetic Acid ; Animals ; Antioxidants - metabolism ; Basic Research ; Cell Adhesion - drug effects ; Colitis - chemically induced ; Colitis - pathology ; Colitis - prevention & control ; Colon - metabolism ; Colon - pathology ; Disease Models, Animal ; Intestinal Mucosa - pathology ; Male ; Malondialdehyde - metabolism ; Mice ; Mice, Inbred A ; Neutrophils - pathology ; Pectins - pharmacology ; Pectins - therapeutic use ; Peroxidase - metabolism ; Phytotherapy ; Plant Preparations - pharmacology ; Plant Preparations - therapeutic use ; Vaccinium - chemistry ; 果胶多糖</subject><ispartof>World journal of gastroenterology : WJG, 2006-11, Vol.12 (41), p.6646-6651</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2006 Baishideng Publishing Group Co., Limited. All rights reserved. 2006</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-3305be0d043699a8aed3acab8352b45c075dac289437325f784aa57c8c6092873</citedby><cites>FETCH-LOGICAL-c338t-3305be0d043699a8aed3acab8352b45c075dac289437325f784aa57c8c6092873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125670/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125670/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17075978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Popov, Sergey V</creatorcontrib><creatorcontrib>Markov, Pavel A</creatorcontrib><creatorcontrib>Nikitina, Ida-R</creatorcontrib><creatorcontrib>Petrishev, Sergey</creatorcontrib><creatorcontrib>Smirnov, Vasily</creatorcontrib><creatorcontrib>Ovodov, Yury S</creatorcontrib><title>Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM： To study isolation and chemical characterization of pectin derived from the common cranberry Vaccin/um oxycoccos L. （oxycoccusan OP） and the testing of its preventive effect on experimental colitis. METHODS： Mice were administrated orally with OP two days prior to a rectal injection of 5% acetic acid and examined for colonic damage 24 h later. Colonic inflammation was characterized by macroscopical injury and enhanced levels of myeloperoxidase activity measured spectrophotometrically with o-phenylene diamine as the substrate. The mucus contents of the colon were determined by the Alcian blue dye binding method. Vascular permeability was estimated using 4% Evans blue passage after i.p. injection of 0.05 mol/L acetic acid. RESULTS： In the mice treated with OP, colonic macroscopic scores （1.1 ± 0.4 vs 2.7, P 〈 0.01） and the total square area of damage （10 ± 2 vs 21 ± 7, P 〈 0.01） were significantly reduced when compared with the vehicle-treated colitis group. OP was shown to decrease the tissue myeloperoxidase activity in colons （42 ± 11 vs 112 ± 40, P 〈 0.01） and enhance the amount of mucus of colitis mice （0.9 ± 0.1 vs 0.4 ± 0.1, P 〈 0.01）. The level of colonic malondialdehyde was noted to decrease in OP-pretreated mice （3.6 ± 0.7 vs 5.1 ± 0.8, P 〈 0.01）. OP was found to decrease the inflammatory status of mice as was determined by reduction of vascular permeability （161 ± 34 vs 241 ± 21, P 〈 0.01）. Adhesion of peritoneal neutrophils and macrophages was also shown to decrease after administration of OP （141 ± 50 vs 235 ± 37, P 〈 0.05）. CONCLUSION： Thus, a preventive effect of pectin from the common cranberry, namely oxycoccusan OP, on acetic acid-induced colitis in mice was detected. A reduction of neutrophil infiltration and antioxidant action may be implicated in the protective effect of oxycoccusan.</description><subject>Acetic Acid</subject><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Basic Research</subject><subject>Cell Adhesion - drug effects</subject><subject>Colitis - chemically induced</subject><subject>Colitis - pathology</subject><subject>Colitis - prevention & control</subject><subject>Colon - metabolism</subject><subject>Colon - pathology</subject><subject>Disease Models, Animal</subject><subject>Intestinal Mucosa - pathology</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred A</subject><subject>Neutrophils - pathology</subject><subject>Pectins - pharmacology</subject><subject>Pectins - therapeutic use</subject><subject>Peroxidase - metabolism</subject><subject>Phytotherapy</subject><subject>Plant Preparations - pharmacology</subject><subject>Plant Preparations - therapeutic use</subject><subject>Vaccinium - chemistry</subject><subject>果胶多糖</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNpVkc2P0zAQxS0EYrsLd07IQlwT_JXYuSCh1cIiVYIDcLUmE6d1SezipF165S_HUSs-TrY0v_dmnh4hLzgrpVbmzcNuUx65KL3iZV2r-hFZCcGbQhjFHpMVZ0wXjRT6ilxP044xIWUlnpIrrpmuGm1W5Nfn5I4uzP7oqOt7hzONPQW6zz-PdB-H0wSIW0i-c8to3jqKcRxjoJggtC6lE_2WER_8YaTx5wkjYpzouqSZAXSLD6DvCh-6A7ouywc_-4n6QEeP7hl50sMwueeX94Z8fX_35fa-WH_68PH23bpAKc1cSMmq1rGOKVk3DRhwnQSE1uRIraowJ-oAhWmU1FJUvTYKoNJosGaNMFrekLdn3_2hHV2HOXWCwe6THyGdbARv_58Ev7WbeLSKi6rWLBu8Phs8QOghbOwuHlLIJ9vcg2CsVpxxnjF2xjDFaUqu_7OCM7vUtuA212ZzbXapLUte_nvaX8Glpwy8unhuY9j88Hl5C_i994OzQgqlaiXkbyj3oj8</recordid><startdate>20061107</startdate><enddate>20061107</enddate><creator>Popov, Sergey V</creator><creator>Markov, Pavel A</creator><creator>Nikitina, Ida-R</creator><creator>Petrishev, Sergey</creator><creator>Smirnov, Vasily</creator><creator>Ovodov, Yury S</creator><general>Department of Molecular Immunology and Biotechnology, Institute of Physiology, Komi Science Centre, The Urals Branch of the Russian Academy of Sciences, 50 Pervomaiskaya str., Syktyvkar 167982, Russia</general><general>Baishideng Publishing Group Co., Limited</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20061107</creationdate><title>Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice</title><author>Popov, Sergey V ; Markov, Pavel A ; Nikitina, Ida-R ; Petrishev, Sergey ; Smirnov, Vasily ; Ovodov, Yury S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-3305be0d043699a8aed3acab8352b45c075dac289437325f784aa57c8c6092873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acetic Acid</topic><topic>Animals</topic><topic>Antioxidants - metabolism</topic><topic>Basic Research</topic><topic>Cell Adhesion - drug effects</topic><topic>Colitis - chemically induced</topic><topic>Colitis - pathology</topic><topic>Colitis - prevention & control</topic><topic>Colon - metabolism</topic><topic>Colon - pathology</topic><topic>Disease Models, Animal</topic><topic>Intestinal Mucosa - pathology</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred A</topic><topic>Neutrophils - pathology</topic><topic>Pectins - pharmacology</topic><topic>Pectins - therapeutic use</topic><topic>Peroxidase - metabolism</topic><topic>Phytotherapy</topic><topic>Plant Preparations - pharmacology</topic><topic>Plant Preparations - therapeutic use</topic><topic>Vaccinium - chemistry</topic><topic>果胶多糖</topic><toplevel>online_resources</toplevel><creatorcontrib>Popov, Sergey V</creatorcontrib><creatorcontrib>Markov, Pavel A</creatorcontrib><creatorcontrib>Nikitina, Ida-R</creatorcontrib><creatorcontrib>Petrishev, Sergey</creatorcontrib><creatorcontrib>Smirnov, Vasily</creatorcontrib><creatorcontrib>Ovodov, Yury S</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>中國數字化期刊數據庫</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Popov, Sergey V</au><au>Markov, Pavel A</au><au>Nikitina, Ida-R</au><au>Petrishev, Sergey</au><au>Smirnov, Vasily</au><au>Ovodov, Yury S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2006-11-07</date><risdate>2006</risdate><volume>12</volume><issue>41</issue><spage>6646</spage><epage>6651</epage><pages>6646-6651</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><notes>Common cranberry Vaccinium oxycoccos L</notes><notes>14-1219/R</notes><notes>R574</notes><notes>Pectin</notes><notes>Mice</notes><notes>Colitis</notes><notes>Anti-inflammatory</notes><notes>Common cranberry Vaccinium oxycoccos L; Pectin; Colitis; Anti-inflammatory; Mice</notes><notes>Correspondence to: Dr. Sergey V Popov, Institute of Physiology, Komi Science Centre, the Urals Branch of the Russian Academy of Sciences, 50 Pervomaiskaya str., Syktyvkar 167982, Russia. popov@physiol.komisc.ru</notes><notes>Telephone: +7-8212-241001 Fax: +7-8212-241001</notes><notes>Supported by the Program of Presidium of the Russian Acad. Sci. «Molecular and cellular biology», by the Russian Fund for Basic Research, No. 06-04-48079 and by the Program for Leading Scientific Schools, No. 5796.2006.4</notes><abstract>AIM： To study isolation and chemical characterization of pectin derived from the common cranberry Vaccin/um oxycoccos L. （oxycoccusan OP） and the testing of its preventive effect on experimental colitis. METHODS： Mice were administrated orally with OP two days prior to a rectal injection of 5% acetic acid and examined for colonic damage 24 h later. Colonic inflammation was characterized by macroscopical injury and enhanced levels of myeloperoxidase activity measured spectrophotometrically with o-phenylene diamine as the substrate. The mucus contents of the colon were determined by the Alcian blue dye binding method. Vascular permeability was estimated using 4% Evans blue passage after i.p. injection of 0.05 mol/L acetic acid. RESULTS： In the mice treated with OP, colonic macroscopic scores （1.1 ± 0.4 vs 2.7, P 〈 0.01） and the total square area of damage （10 ± 2 vs 21 ± 7, P 〈 0.01） were significantly reduced when compared with the vehicle-treated colitis group. OP was shown to decrease the tissue myeloperoxidase activity in colons （42 ± 11 vs 112 ± 40, P 〈 0.01） and enhance the amount of mucus of colitis mice （0.9 ± 0.1 vs 0.4 ± 0.1, P 〈 0.01）. The level of colonic malondialdehyde was noted to decrease in OP-pretreated mice （3.6 ± 0.7 vs 5.1 ± 0.8, P 〈 0.01）. OP was found to decrease the inflammatory status of mice as was determined by reduction of vascular permeability （161 ± 34 vs 241 ± 21, P 〈 0.01）. Adhesion of peritoneal neutrophils and macrophages was also shown to decrease after administration of OP （141 ± 50 vs 235 ± 37, P 〈 0.05）. CONCLUSION： Thus, a preventive effect of pectin from the common cranberry, namely oxycoccusan OP, on acetic acid-induced colitis in mice was detected. A reduction of neutrophil infiltration and antioxidant action may be implicated in the protective effect of oxycoccusan.</abstract><cop>United States</cop><pub>Department of Molecular Immunology and Biotechnology, Institute of Physiology, Komi Science Centre, The Urals Branch of the Russian Academy of Sciences, 50 Pervomaiskaya str., Syktyvkar 167982, Russia</pub><pmid>17075978</pmid><doi>10.3748/wjg.v12.i41.6646</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetic Acid Animals Antioxidants - metabolism Basic Research Cell Adhesion - drug effects Colitis - chemically induced Colitis - pathology Colitis - prevention & control Colon - metabolism Colon - pathology Disease Models, Animal Intestinal Mucosa - pathology Male Malondialdehyde - metabolism Mice Mice, Inbred A Neutrophils - pathology Pectins - pharmacology Pectins - therapeutic use Peroxidase - metabolism Phytotherapy Plant Preparations - pharmacology Plant Preparations - therapeutic use Vaccinium - chemistry 果胶多糖 |
| title | Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice |
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