Preclinical non-human models to combat dementia

Dementia is characterized by a certain degree of memory loss with disabled intellectual functioning, which mostly presents as Alzheimer's disease. The underlying causes range from gene mutations, lifestyle factors, and other environmental influences to brain injuries and normal aging. Although...

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Bibliographic Details
Published in:Annals of Neurosciences 2013-01, Vol.20 (1), p.24-29
Main Authors: Banik, Avijit, Anand, Akshay
Format: Article
Language:English
Subjects:
Comprehensive Review
Dementia
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Summary:Dementia is characterized by a certain degree of memory loss with disabled intellectual functioning, which mostly presents as Alzheimer's disease. The underlying causes range from gene mutations, lifestyle factors, and other environmental influences to brain injuries and normal aging. Although there have been many rodent and non-human primate models created by various drugs, neurotoxins and genetic ablation but the current scenario does not exhibit a well characterized animal model to evaluate novel compounds and various treatment strategies for dementia. Therefore, a comprehensive model exhibiting the pathologies and neuro-behavioral parameters close to this syndrome is very much needed. This report discusses the various experimental strategies to create animal models of dementia.
ISSN:0972-7531
0976-3260
DOI:10.5214/ans.0972.7531.200109