Proliferation, differentiation and amyloid-β production in neural progenitor cells isolated from TgCRND8 mice

Highlights • In young TgCRND8 mice, proliferation of newborn cells in dentate gyrus is increased, compared with Non-Tg control mice. • On the contrary, differentiation to neural progenitor cells of newborn cells in the TgCRND8 hippocampus is impaired. • Neurosphere cultures isolated from hippocampi...

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Bibliographic Details
Published in:Neuroscience 2014-03, Vol.261 (100), p.52-59
Main Authors: Kanemoto, S, Griffin, J, Markham-Coultes, K, Aubert, I, Tandon, A, George-Hyslop, P.S, Fraser, P.E
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Alzheimer Disease
Alzheimer’s disease
amyloid
Amyloid beta-Peptides - metabolism
Amyloid beta-Protein Precursor - genetics
Amyloid beta-Protein Precursor - metabolism
Amyloid Precursor Protein Secretases - metabolism
Animals
Biological and medical sciences
Cell Count
Cell Survival - physiology
Cells, Cultured
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dentate Gyrus - physiology
DNA-Binding Proteins
Glial Fibrillary Acidic Protein
Hippocampus - physiology
Immunohistochemistry
Medical sciences
Mice
Mice, Transgenic
Nerve Tissue Proteins - metabolism
neural progenitor cells
Neural Stem Cells - physiology
Neurogenesis - physiology
Neuroglia - physiology
Neurology
Neurons - physiology
Nuclear Proteins - metabolism
Organic mental disorders. Neuropsychology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
S100 Calcium Binding Protein beta Subunit - metabolism
transgenic mice
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Summary:Highlights • In young TgCRND8 mice, proliferation of newborn cells in dentate gyrus is increased, compared with Non-Tg control mice. • On the contrary, differentiation to neural progenitor cells of newborn cells in the TgCRND8 hippocampus is impaired. • Neurosphere cultures isolated from hippocampi of TgCRND8 mice show low viability than those from Non-Tg control. • Neurosphere cultures from TgCRND8 mice secrete high levels of Aβ peptide.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.12.021