Investigation of the Cytotoxic Effects of Titanate Nanotubes on Caco-2 Cells

Titanate nanotubes can be used as drug delivery systems, but limited information is available on their interactions with intestinal cells. In this study, we investigated the cytotoxicity and cellular uptake of titanate nanotubes on Caco-2 monolayers and found that up to 5 mg/ml concentration, these...

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Bibliographic Details
Published in:AAPS PharmSciTech 2014-08, Vol.15 (4), p.858-861
Main Authors: Fenyvesi, Ferenc, Kónya, Zoltán, Rázga, Zsolt, Vecsernyés, Miklós, Kása, Péter, Pintye-Hódi, Klára, Bácskay, Ildikó
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Caco-2 Cells
Cell Line, Tumor
Drug Delivery Systems
Humans
Intestines - drug effects
Nanotubes - adverse effects
Nanotubes - chemistry
Permeability
Pharmacology/Toxicology
Pharmacy
Rapid Communication
Titanium - adverse effects
Titanium - chemistry
Titanium - pharmacology
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Summary:Titanate nanotubes can be used as drug delivery systems, but limited information is available on their interactions with intestinal cells. In this study, we investigated the cytotoxicity and cellular uptake of titanate nanotubes on Caco-2 monolayers and found that up to 5 mg/ml concentration, these nanotubes are not cytotoxic and not able to permeate through the intestinal cell layer. Transmission electron microscopic experiments showed that titanate nanotubes are not taken up by cells, only caused a high-density granulation on the surface of the endoplasmic reticulum. According to these results, titanate nanotubes are suitable systems for intestinal drug delivery.
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-014-0115-x