Fluoroquinolone-based protocols for eradication of Helicobacter pylori

Helicobacter pylori(H. pylori) is a widespread pathogen infecting about 40% of people living in urban areas and over 90% of people living in the developing regions of the world. H. pylori is well-documented as the main factor in the pathogenesis of peptic ulcer disease, chronic gastritis, and gastri...

Full description

Saved in:
Bibliographic Details
Published in:World journal of gastroenterology : WJG 2014-07, Vol.20 (27), p.8947-8956
Main Authors: Rispo, Antonio, Capone, Pietro, Castiglione, Fabiana, Pasquale, Luigi, Rea, Matilde, Caporaso, Nicola
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - therapeutic use
Drug Resistance, Bacterial
Drug Substitution
Drug Therapy, Combination
eradication
fluoroquinolone
Fluoroquinolones - therapeutic use
Helicobacter
Helicobacter Infections - diagnosis
Helicobacter Infections - drug therapy
Helicobacter Infections - microbiology
Helicobacter pylori - drug effects
Helicobacter pylori - pathogenicity
Humans
Practice Guidelines as Topic
Proton Pump Inhibitors - therapeutic use
pylori
Topic Highlight
Treatment Outcome
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Helicobacter pylori(H. pylori) is a widespread pathogen infecting about 40% of people living in urban areas and over 90% of people living in the developing regions of the world. H. pylori is well-documented as the main factor in the pathogenesis of peptic ulcer disease, chronic gastritis, and gastric malignancies such as cancer and mucosa-associated lymphoid tissuelymphoma; hence, its eradication is strongly recommended. the Maastricht Ⅳ consensus, which focused on the management of H. pylori infection, set important new strategies in terms of treatment approaches, particularly with regards to first- and second-line treatment protocols and led to improved knowledge and understanding of H. pylori resistance to antibiotics. In recent years, various fluoroquinolone-based protocols, mainly including levofloxacin, have been proposed and effectively tested at all therapeutic lines for H. pylori eradication. the aim of the present paper is to review the scientific literature focused on the use of fluoroquinolones in eradicating H. pylori.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v20.i27.8947