No association of maternal vitamin E intake with higher risk of cardiovascular malformations in children: a population-based case–control study

Objective:In Hungary, vitamin E is frequently used to prevent repeated or threatened abortion. A previous study showed a higher risk of cardiovascular malformations in the children of pregnant women who had a high vitamin E intake either in their diet or by taking supplements. The objective was to e...

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Bibliographic Details
Published in:Therapeutic advances in drug safety 2011-06, Vol.2 (3), p.77-86
Main Authors: Szilasi, Mária, Bártfai, Liza, Bártfai, Zoltán, Bánhidy, Ferenc, Czeizel, Andrew E.
Format: Article
Language:English
Subjects:
Original Research
Population-based studies
Pregnancy
Vitamin E
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Summary:Objective:In Hungary, vitamin E is frequently used to prevent repeated or threatened abortion. A previous study showed a higher risk of cardiovascular malformations in the children of pregnant women who had a high vitamin E intake either in their diet or by taking supplements. The objective was to examine this association. Methods:The Hungarian Case–Control Surveillance System of Congenital Abnormalities, 1980–1996, is a large, population-based dataset including 22,843 cases with congenital abnormalities, 38,151 healthy controls matched to the cases, and 834 patient controls with Down syndrome. Vitamin E treatment was compared in the mothers of these children. Results:The mothers of 1418 cases with congenital abnormalities (6.2%), 2267 controls (6.0%) and 43 patient controls (5.2%) had vitamin E treatment during pregnancy. A preliminary comparison of cases and controls showed a higher risk for four congenital abnormality groups, including cardiovascular malformations. However, if only prospectively and medically recorded vitamin E treatments in the prenatal maternity logbook were evaluated during the critical period of different congenital abnormalities, the higher risk for these congenital abnormalities was not found. Conclusions:The results of this study were based on relatively high-dose vitamin E intake in pregnant women and were not able to confirm the previously reported teratogenic effect of vitamin E.
ISSN:2042-0986
2042-0994
DOI:10.1177/2042098611406946