The effect of triclosan coated sutures on rate of surgical site infection after hip and knee replacement: a protocol for a double-blind randomised controlled trial

187,000 hip and knee joint replacements are performed every year in the National Health Service (NHS). One of the commonest complications is surgical site infection (SSI), and this represents a significant burden in terms of patient morbidity, mortality and cost to health services around the world....

Full description

Saved in:

Bibliographic Details
Published in:	BMC musculoskeletal disorders 2014-07, Vol.15 (1), p.237-237, Article 237
Main Authors:	Sprowson, Andrew P, Jensen, Cyrus D, Parsons, Nick, Partington, Paul, Emmerson, Kevin, Carluke, Ian, Asaad, Seif, Pratt, Roland, Muller, Scott, Reed, Mike R
Format:	Article
Language:	eng
Subjects:	Analysis Anti-Infective Agents, Local - administration & dosage Anti-Infective Agents, Local - economics Arthroplasty, Replacement, Hip - adverse effects Arthroplasty, Replacement, Hip - economics Arthroplasty, Replacement, Hip - instrumentation Arthroplasty, Replacement, Knee - adverse effects Arthroplasty, Replacement, Knee - economics Arthroplasty, Replacement, Knee - instrumentation Clinical Protocols Coated Materials, Biocompatible - economics Double-Blind Method Economic aspects England Evidence (Law) Health aspects Health Care Costs Humans Length of Stay Medical care, Cost of Research Design Study Protocol Surgical Wound Infection - economics Surgical Wound Infection - etiology Surgical Wound Infection - prevention & control Suture Techniques - adverse effects Suture Techniques - economics Suture Techniques - instrumentation Sutures - economics Time Factors Treatment Outcome Triclosan - administration & dosage Triclosan - economics
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	187,000 hip and knee joint replacements are performed every year in the National Health Service (NHS). One of the commonest complications is surgical site infection (SSI), and this represents a significant burden in terms of patient morbidity, mortality and cost to health services around the world. The aim of this randomised controlled trial (RCT) is to determine if the addition of triclosan coated sutures to a standard regimen can reduce the rate of SSI after total knee replacement (TKR) and total hip replacement (THR). 2400 patients due to undergo a total hip or knee replacement are being recruited into this two-centre RCT. Participants are recruited before surgery and randomised to either standard care or intervention group. Participants, outcome assessors and statistician are blind to treatment allocation throughout the study. The intervention consists of triclosan coated sutures vs. standard non-coated sutures. The primary outcome is the Health protection Agency (HPA) defined superficial surgical site infection at 30 days. Secondary outcomes include HPA defined deep surgical site infection at 12 months, length of hospital stay, critical care stay, and payer costs. To date there are no orthopaedic randomised controlled trials on this scale assessing the effectiveness of a surgical intervention, particularly those that can be translated across the surgical specialities. The results from this trial will inform evidence-based recommendations for suture selection in the management of patients undergoing total hip or knee replacement. If triclosan coated sutures are found to be an effective intervention, implementation into clinical practice could improve long-term outcomes for patients undergoing hip and knee replacement. Current Controlled Trials ISRCTN 17807356.
ISSN:	1471-2474 1471-2474